Predictors of Mortality in Critically Ill COVID-19 Patients Demanding High Oxygen Flow: A Thin Line between Inflammation, Cytokine Storm, and Coagulopathy.
Adult
Aged
Aged, 80 and over
Blood Coagulation Disorders
/ blood
COVID-19
/ complications
Critical Care
Critical Illness
Cytokine Release Syndrome
/ blood
Female
Fibrin Fibrinogen Degradation Products
/ analysis
Humans
Intensive Care Units
Interleukin-6
/ blood
Length of Stay
Male
Middle Aged
Oxygen Inhalation Therapy
/ methods
Real-Time Polymerase Chain Reaction
Respiration, Artificial
Respiratory Distress Syndrome
/ blood
SARS-CoV-2
/ genetics
Serbia
/ epidemiology
Serum Albumin, Human
/ analysis
Severity of Illness Index
Treatment Outcome
Journal
Oxidative medicine and cellular longevity
ISSN: 1942-0994
Titre abrégé: Oxid Med Cell Longev
Pays: United States
ID NLM: 101479826
Informations de publication
Date de publication:
2021
2021
Historique:
received:
02
12
2020
revised:
21
12
2020
accepted:
06
03
2021
entrez:
10
5
2021
pubmed:
11
5
2021
medline:
21
5
2021
Statut:
epublish
Résumé
Mortality among critically ill COVID-19 patients remains relatively high despite different potential therapeutic modalities being introduced recently. The treatment of critically ill patients is a challenging task, without identified credible predictors of mortality. We performed an analysis of 160 consecutive patients with confirmed COVID-19 infection admitted to the Respiratory Intensive Care Unit between June 23, 2020, and October 2, 2020, in University Hospital Center Bezanijska kosa, Belgrade, Serbia. Patients on invasive, noninvasive ventilation and high flow oxygen therapy with moderate to severe ARDS, according to the Berlin definition of ARDS, were selected for the study. Demographic data, past medical history, laboratory values, and CT severity score were analyzed to identify predictors of mortality. Univariate and multivariate logistic regression models were used to assess potential predictors of mortality in critically ill COVID-19 patients. The mean patient age was 65.6 years (range, 29-92 years), predominantly men, 68.8%. 107 (66.9%) patients were on invasive mechanical ventilation, 31 (19.3%) on noninvasive, and 22 (13.8%) on high flow oxygen therapy machine. The median total number of ICU days was 10 (25 In the present study of 160 consecutive critically ill COVID-19 patients with moderate to severe ARDS, IL-6, serum albumin, and D-dimer at admission to ICU, accompanied by chest CT severity score, were marked as independent predictors of mortality.
Identifiants
pubmed: 33968298
doi: 10.1155/2021/6648199
pmc: PMC8081622
doi:
Substances chimiques
Fibrin Fibrinogen Degradation Products
0
IL6 protein, human
0
Interleukin-6
0
fibrin fragment D
0
Serum Albumin, Human
ZIF514RVZR
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
6648199Informations de copyright
Copyright © 2021 Viseslav Popadic et al.
Déclaration de conflit d'intérêts
The authors declare that there is no conflict of interest regarding the publication of this paper.
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