Standardizing salivary lactoferrin measurements to obtain a robust diagnostic biomarker for Alzheimer's disease.
Alzheimer's disease
aging
biomarker
circadian rhythm
exercise
lactoferrin
measurement
regulatory factors
reproducibility
saliva
treatments
Journal
Alzheimer's & dementia (Amsterdam, Netherlands)
ISSN: 2352-8729
Titre abrégé: Alzheimers Dement (Amst)
Pays: United States
ID NLM: 101654604
Informations de publication
Date de publication:
2021
2021
Historique:
received:
29
11
2020
revised:
01
02
2021
accepted:
18
02
2021
entrez:
10
5
2021
pubmed:
11
5
2021
medline:
11
5
2021
Statut:
epublish
Résumé
The search for new, robust, and reproducible biomarkers for Alzheimer's disease (AD) diagnosis is a challenge. We recently reported that salivary lactoferrin (Lf) could be presented as new biomarker candidate for AD, being both non-invasive and cost-effective, as well as having appropriate diagnostic performance for the clinical detection of AD subjects. Saliva is an attractive sample type for biomarker-based testing approaches for several other diseases; however, its composition may change under certain circumstances. It is therefore critical to maintain a consistent salivary handling protocol, considering possible extrinsic factors that may influence salivary Lf concentration. In this work, we analyzed salivary Lf concentration under different handling conditions and donor-dependent factors including age, inter-diurnal variations, physical activity, and pharmacological treatments. Our aim was to evaluate the influence of such conditions on salivary Lf concentration. In conclusion, we found that most of these extrinsic factors should be considered in the future when using Lf as a predictive biomarker for AD.
Identifiants
pubmed: 33969170
doi: 10.1002/dad2.12173
pii: DAD212173
pmc: PMC8088590
doi:
Types de publication
Journal Article
Langues
eng
Pagination
e12173Informations de copyright
© 2021 The Authors. Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring published by Wiley Periodicals, LLC on behalf of Alzheimer's Association.
Déclaration de conflit d'intérêts
Dr. Eva Carro and Dr. Gorka Orive are co‐founders of GEROA Diagnostics. No other disclosures are reported.
Références
Acta Odontol Scand. 2016 Oct;74(7):576-583
pubmed: 27565888
J Pharm Sci. 2020 Jan;109(1):464-475
pubmed: 31647953
J Periodontal Res. 2012 Oct;47(5):655-60
pubmed: 22471324
J Periodontol. 2001 Jan;72(1):90-5
pubmed: 11210079
Int J Environ Res Public Health. 2019 Nov 12;16(22):
pubmed: 31726719
J Clin Invest. 1990 Sep;86(3):825-31
pubmed: 2203825
Lancet. 2020 Aug 8;396(10248):413-446
pubmed: 32738937
EBioMedicine. 2020 Jul;57:102882
pubmed: 32650274
Br J Sports Med. 2003 Feb;37(1):76-9
pubmed: 12547749
Alzheimers Dement. 2018 Oct;14(10):1313-1333
pubmed: 29940161
Osong Public Health Res Perspect. 2015 Dec;6(6):357-62
pubmed: 26835245
Molecules. 2011 Aug 16;16(8):6992-7018
pubmed: 21847071
Oral Dis. 2021 Mar;27(2):280-289
pubmed: 32643850
J Periodontol. 2008 Dec;79(12):2233-40
pubmed: 19053911
J Sports Sci. 2017 Apr;35(7):617-623
pubmed: 27237844
J Dent. 2005 Mar;33(3):223-33
pubmed: 15725522
Eur J Appl Physiol. 2017 May;117(5):1047-1051
pubmed: 28341903
Graefes Arch Clin Exp Ophthalmol. 2000 Nov;238(11):892-9
pubmed: 11148812
Aging (Milano). 2000 Dec;12(6):445-8
pubmed: 11211954
EBioMedicine. 2020 Jul;57:102834
pubmed: 32586758
Dis Markers. 2019 May 2;2019:4761054
pubmed: 31191751
Biogerontology. 2004;5(4):223-33
pubmed: 15314272
Auton Neurosci. 2007 Apr 30;133(1):3-18
pubmed: 17157080
Cancer Detect Prev. 1985;8(1-2):23-34
pubmed: 2415254
Lancet Neurol. 2004 Jun;3(6):343-53
pubmed: 15157849
Eur J Appl Physiol. 2015 Sep;115(9):1887-95
pubmed: 25893563
Eur J Appl Physiol. 2016 Jun;116(6):1219-29
pubmed: 27129582
Periodontol 2000. 2016 Feb;70(1):11-25
pubmed: 26662479
J Am Med Dir Assoc. 2008 Jul;9(6):390-405
pubmed: 18585641
Alzheimers Dement. 2020 Aug;16(8):1196-1204
pubmed: 32543760
Med Hypotheses. 2021 Jan;146:110393
pubmed: 33229194
Int J Radiat Oncol Biol Phys. 2010 Nov 15;78(4):983-91
pubmed: 20970030
Biol Trace Elem Res. 1997 Apr;57(1):1-8
pubmed: 9258463
Spec Care Dentist. 1996 May-Jun;16(3):95-103
pubmed: 9084322
Biomed J. 2018 Apr;41(2):63-87
pubmed: 29866603
Immunology. 2007 Apr;120(4):435-46
pubmed: 17313487