Sex and APOE genotype differences related to statin use in the aging population.
APOE genotype
Alzheimer's disease
UK Biobank
aging population
statins
Journal
Alzheimer's & dementia (New York, N. Y.)
ISSN: 2352-8737
Titre abrégé: Alzheimers Dement (N Y)
Pays: United States
ID NLM: 101650118
Informations de publication
Date de publication:
2021
2021
Historique:
received:
13
10
2020
revised:
11
01
2021
accepted:
05
02
2021
entrez:
10
5
2021
pubmed:
11
5
2021
medline:
11
5
2021
Statut:
epublish
Résumé
Significant evidence suggests that the cholesterol-lowering statins can affect cognitive function and reduce the risk for Alzheimer's disease (AD) and dementia. These potential effects may be constrained by specific combinations of an individual's sex and apolipoprotein E ( Here we examine data from 252,327 UK Biobank participants, aged 55 or over, and compare the effects of statin use in males and females. We assessed difference in statin treatments taking a matched cohort approach, and identified key stratifiers using regression models and conditional inference trees. Using statistical modeling, we further evaluated the effect of statins on survival, cognitive decline over time, and on AD prevalence. We identified that in the selected population, males were older, had a higher level of education, better cognitive scores, higher incidence of cardiovascular and metabolic diseases, and a higher rate of statin use. We observed that males and those participants with an Our evaluation of the aging population in a large cohort from the UK Biobank confirms sex and
Sections du résumé
BACKGROUND
BACKGROUND
Significant evidence suggests that the cholesterol-lowering statins can affect cognitive function and reduce the risk for Alzheimer's disease (AD) and dementia. These potential effects may be constrained by specific combinations of an individual's sex and apolipoprotein E (
METHODS
METHODS
Here we examine data from 252,327 UK Biobank participants, aged 55 or over, and compare the effects of statin use in males and females. We assessed difference in statin treatments taking a matched cohort approach, and identified key stratifiers using regression models and conditional inference trees. Using statistical modeling, we further evaluated the effect of statins on survival, cognitive decline over time, and on AD prevalence.
RESULTS
RESULTS
We identified that in the selected population, males were older, had a higher level of education, better cognitive scores, higher incidence of cardiovascular and metabolic diseases, and a higher rate of statin use. We observed that males and those participants with an
DISCUSSION
CONCLUSIONS
Our evaluation of the aging population in a large cohort from the UK Biobank confirms sex and
Identifiants
pubmed: 33969178
doi: 10.1002/trc2.12156
pii: TRC212156
pmc: PMC8088592
doi:
Types de publication
Journal Article
Langues
eng
Pagination
e12156Subventions
Organisme : Medical Research Council
ID : MC_PC_17228
Pays : United Kingdom
Organisme : NIA NIH HHS
ID : R34 AG049652
Pays : United States
Organisme : Medical Research Council
ID : MR/N00583X/1
Pays : United Kingdom
Organisme : NIA NIH HHS
ID : P01 AG026572
Pays : United States
Organisme : Medical Research Council
ID : MC_QA137853
Pays : United Kingdom
Informations de copyright
© 2021 The Authors. Alzheimer's & Dementia: Translational Research & Clinical Interventions published by Wiley Periodicals LLC on behalf of Alzheimer's Association.
Déclaration de conflit d'intérêts
The authors have no financial conflicts of interest.
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