The landscape of cell-cell communication through single-cell transcriptomics.
Journal
Current opinion in systems biology
ISSN: 2452-3100
Titre abrégé: Curr Opin Syst Biol
Pays: England
ID NLM: 101698476
Informations de publication
Date de publication:
Jun 2021
Jun 2021
Historique:
entrez:
10
5
2021
pubmed:
11
5
2021
medline:
11
5
2021
Statut:
ppublish
Résumé
Cell-cell communication is a fundamental process that shapes biological tissue. Historically, studies of cell-cell communication have been feasible for one or two cell types and a few genes. With the emergence of single-cell transcriptomics, we are now able to examine the genetic profiles of individual cells at unprecedented scale and depth. The availability of such data presents an exciting opportunity to construct a more comprehensive description of cell-cell communication. This review discusses the recent explosion of methods that have been developed to infer cell-cell communication from non-spatial and spatial single-cell transcriptomics, two promising technologies which have complementary strengths and limitations. We propose several avenues to propel this rapidly expanding field forward in meaningful ways.
Identifiants
pubmed: 33969247
doi: 10.1016/j.coisb.2021.03.007
pmc: PMC8104132
mid: NIHMS1687742
doi:
Types de publication
Journal Article
Langues
eng
Pagination
12-23Subventions
Organisme : NIAMS NIH HHS
ID : P30 AR075047
Pays : United States
Organisme : NIAMS NIH HHS
ID : U01 AR073159
Pays : United States
Déclaration de conflit d'intérêts
Declaration of interests The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
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