Reduced A-to-I editing of endogenous Alu RNAs in lung after SARS-CoV-2 infection.
A-to-I editing
A-to-I, adenosine-to-inosine
Alu RNAs
Double-stranded RNA sensors
EEL, editing enriched location
IRs, inverted repeats
ISGs, interferon-stimulated genes
NHBE, normal human bronchial epithelial cells
RNA-seq, whole genome RNA-sequencing
SARS-CoV-2
SARS-CoV-2, severe acute respiratory syndrome coronavirus 2
Journal
Current research in immunology
ISSN: 2590-2555
Titre abrégé: Curr Res Immunol
Pays: Netherlands
ID NLM: 101776898
Informations de publication
Date de publication:
2021
2021
Historique:
received:
16
03
2021
revised:
19
04
2021
accepted:
22
04
2021
entrez:
10
5
2021
pubmed:
11
5
2021
medline:
11
5
2021
Statut:
ppublish
Résumé
Due to potential severity of disease caused by SARS-CoV-2 infection, it is critical to understand both mechanisms of viral pathogenesis as well as diversity of host responses to infection. Reduced A-to-I editing of endogenous double-stranded RNAs (dsRNAs), as a result of inactivating mutations in
Identifiants
pubmed: 33969287
doi: 10.1016/j.crimmu.2021.04.001
pii: S2590-2555(21)00007-X
pmc: PMC8084883
doi:
Types de publication
Journal Article
Langues
eng
Pagination
52-59Informations de copyright
© 2021 The Author(s).
Déclaration de conflit d'intérêts
The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
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