Fostering healthy aging: The interdependency of infections, immunity and frailty.
Frailty
Healthy aging
Immunosenescence
Vaccination
Journal
Ageing research reviews
ISSN: 1872-9649
Titre abrégé: Ageing Res Rev
Pays: England
ID NLM: 101128963
Informations de publication
Date de publication:
08 2021
08 2021
Historique:
received:
16
12
2020
revised:
16
04
2021
accepted:
03
05
2021
pubmed:
11
5
2021
medline:
22
6
2021
entrez:
10
5
2021
Statut:
ppublish
Résumé
Untangling the interdependency of infections, immunity and frailty may help to clarify their roles in the maintenance of health in aging individuals, and the recent COVID-19 pandemic has further highlighted such priority. In this scoping review we aimed to systematically collect the evidence on 1) the impact of common infections such as influenza, pneumonia and varicella zoster on frailty development, and 2) the role played by frailty in the response to immunization of older adults. Findings are discussed under a unifying framework to identify knowledge gaps and outline their clinical and public health implications to foster a healthier aging. Twenty-nine studies (113,863 participants) selected to answer the first question provided a moderately strong evidence of an association between infections and physical as well as cognitive decline - two essential dimensions of frailty. Thirteen studies (34,520 participants) investigating the second aim, showed that frailty was associated with an impaired immune response in older ages, likely due to immunosenescence. However, the paucity of studies, the absence of tools to predict vaccine efficacy, and the lack of studies investigating the efficacy of newer vaccines in presence of frailty, strongly limit the formulation of more personalized immunization strategies for older adults. The current evidence suggests that infections and frailty repeatedly cross each other pathophysiological paths and accelerate the aging process in a vicious circle. Such evidence opens to several considerations. First, the prevention of both conditions pass through a life course approach, which includes several individual and societal aspects. Second, the maintenance of a well-functioning immune system may be accomplished by preventing frailty, and vice versa. Third, increasing the adherence to immunization may delay the onset of frailty and maintain the immune system homeostasis, beyond preventing infections.
Identifiants
pubmed: 33971332
pii: S1568-1637(21)00098-2
doi: 10.1016/j.arr.2021.101351
pmc: PMC9588151
pii:
doi:
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
101351Subventions
Organisme : Medical Research Council
ID : MR/V005030/1
Pays : United Kingdom
Informations de copyright
Copyright © 2021 The Author(s). Published by Elsevier B.V. All rights reserved.
Références
Vaccine. 2011 Jul 12;29(31):5015-21
pubmed: 21565245
Eur J Vasc Endovasc Surg. 2018 Oct;56(4):591-602
pubmed: 30122332
Mech Ageing Dev. 2012 Jun;133(6):456-66
pubmed: 22663935
Dig Liver Dis. 2018 Jun;50(6):533-541
pubmed: 29628357
Biogerontology. 2015 Dec;16(6):693-707
pubmed: 26349923
N Engl J Med. 2016 Sep 15;375(11):1019-32
pubmed: 27626517
Eur J Public Health. 2020 Feb 1;30(1):132-141
pubmed: 30597009
Cochrane Database Syst Rev. 2018 Feb 01;2:CD004876
pubmed: 29388197
Exp Gerontol. 2014 Jun;54:1-5
pubmed: 24291068
JAMA. 2010 Oct 27;304(16):1787-94
pubmed: 20978258
Aging (Albany NY). 2019 Nov 9;11(21):9234-9263
pubmed: 31707363
Hum Vaccin Immunother. 2013 Apr;9(4):907-10
pubmed: 23319202
J Gerontol A Biol Sci Med Sci. 2021 Feb 25;76(3):e38-e45
pubmed: 33216846
Lancet. 2013 Mar 2;381(9868):752-62
pubmed: 23395245
Cochrane Database Syst Rev. 2019 Nov 7;2019(11):
pubmed: 31696946
Thorax. 2019 May;74(5):473-482
pubmed: 30355641
Heart. 2015 Nov;101(21):1738-47
pubmed: 26310262
J Am Med Dir Assoc. 2014 Mar;15(3):226.e1-226.e6
pubmed: 24321878
JAMA Cardiol. 2019 Nov 1;4(11):1084-1091
pubmed: 31553402
Cell. 2013 Jun 6;153(6):1194-217
pubmed: 23746838
PLoS One. 2017 Jan 6;12(1):e0169368
pubmed: 28061505
BMC Med. 2019 Oct 2;17(1):185
pubmed: 31575376
CA Cancer J Clin. 2017 Sep;67(5):362-377
pubmed: 28731537
Age Ageing. 2011 Jan;40(1):35-41
pubmed: 21148323
Maturitas. 2015 Sep;82(1):50-5
pubmed: 26044074
Lancet. 2009 May 30;373(9678):1874-82
pubmed: 19446324
Exp Mol Med. 2019 Dec 11;51(12):1-6
pubmed: 31827063
J Cell Mol Med. 2009 Sep;13(9B):3103-9
pubmed: 19438806
Ann Am Thorac Soc. 2016 Jun;13(6):933-44
pubmed: 27088424
Age Ageing. 2014 Sep;43(5):687-95
pubmed: 24742587
Nat Rev Cardiol. 2018 Sep;15(9):505-522
pubmed: 30065258
Am J Respir Crit Care Med. 2013 Sep 1;188(5):586-92
pubmed: 23848267
J Int Med Res. 2018 Jun;46(6):2265-2283
pubmed: 29609489
Lancet Neurol. 2020 Jun;19(6):533-543
pubmed: 32470425
Clin Drug Investig. 2018 Jan;38(1):29-37
pubmed: 29086340
Vaccine. 2018 Feb 8;36(7):921-931
pubmed: 29336923
J Gerontol A Biol Sci Med Sci. 2020 Nov 13;75(12):2320-2325
pubmed: 32877922
Int J Epidemiol. 2016 Aug;45(4):973-988
pubmed: 27880685
Vaccine. 2018 Jun 14;36(25):3635-3640
pubmed: 29748031
J Gerontol A Biol Sci Med Sci. 2018 Sep 11;73(10):1350-1356
pubmed: 28957993
Vaccine. 2015 Aug 26;33(36):4565-71
pubmed: 26187260
Ann Neurol. 2019 Jul;86(1):68-78
pubmed: 31066941
J Am Geriatr Soc. 2007 Jun;55(6):864-71
pubmed: 17537086
Vaccine. 2017 Apr 25;35(18):2315-2328
pubmed: 28343775
Vaccine. 2017 May 19;35(22):2882-2891
pubmed: 28449971
Ageing Res Rev. 2020 Nov;63:101149
pubmed: 32818650
J Am Geriatr Soc. 2016 May;64(5):998-1005
pubmed: 27131018
J Am Geriatr Soc. 2006 Dec;54(12):1861-70
pubmed: 17198491
Immunol Invest. 2018 Nov;47(8):801-811
pubmed: 31282802
Lancet Public Health. 2017 Feb;2(2):e74-e81
pubmed: 28299371
Front Immunol. 2017 Aug 15;8:982
pubmed: 28861086
N Engl J Med. 2015 May 28;372(22):2087-96
pubmed: 25916341
BMC Public Health. 2015 May 05;15:466
pubmed: 25940080
Vaccine. 2010 Jan 8;28(3):864-7
pubmed: 19931952
PLoS One. 2014 Apr 23;9(4):e94578
pubmed: 24760002
Eur J Intern Med. 2018 Oct;56:53-56
pubmed: 29950278
Clin Microbiol Infect. 2018 Jan;24(1):72-77
pubmed: 28583738
Lancet Public Health. 2020 Aug;5(8):e444-e451
pubmed: 32619408
Crit Care Med. 2014 May;42(5):1037-46
pubmed: 24368344
Immun Ageing. 2017 Jul 6;14:17
pubmed: 28694834
J Gerontol A Biol Sci Med Sci. 2007 Jul;62(7):717-21
pubmed: 17634317
J Neurol. 1997 Apr;244(4):239-45
pubmed: 9112592
Vaccine. 2009 Mar 4;27(10):1628-36
pubmed: 19100304
Age Ageing. 2018 May 01;47(3):392-397
pubmed: 29309502
Exp Gerontol. 2019 Sep;124:110625
pubmed: 31173841
Physiol Rev. 2018 Jul 1;98(3):1417-1464
pubmed: 29767563
Arch Bronconeumol. 2015 Oct;51(10):496-501
pubmed: 25605525
Vaccine. 2007 Jul 20;25(29):5390-8
pubmed: 17583392
Front Immunol. 2018 Jan 10;8:1960
pubmed: 29375577
Expert Rev Vaccines. 2011 Aug;10(8):1143-67
pubmed: 21810065
Nat Med. 2019 Dec;25(12):1822-1832
pubmed: 31806905
J Am Geriatr Soc. 2011 Feb;59(2):327-32
pubmed: 21275932
Vaccine. 2018 Aug 9;36(33):4979-4992
pubmed: 30037416
Ageing Res Rev. 2017 May;35:36-45
pubmed: 28109835
Exerc Immunol Rev. 2004;10:6-41
pubmed: 15633584
Nutr Rev. 2017 Jun 1;75(6):442-455
pubmed: 28595318
Mech Ageing Dev. 2009 Mar;130(3):161-6
pubmed: 19027777
BMC Med. 2010 Jun 21;8:37
pubmed: 20565946
Crit Care Med. 2014 May;42(5):1282-3
pubmed: 24736335
J Gerontol A Biol Sci Med Sci. 2019 Jul 12;74(8):1225-1230
pubmed: 30576411
Gut. 2016 Nov;65(11):1906-1915
pubmed: 27531828
J Gerontol A Biol Sci Med Sci. 2007 Jul;62(7):722-7
pubmed: 17634318
Acta Paediatr. 2018 May 17;:
pubmed: 29771465
Influenza Other Respir Viruses. 2019 Jul;13(4):391-397
pubmed: 30848082
J Intern Med. 2019 Mar;285(3):255-271
pubmed: 30357990
Vaccine. 2005 Jun 10;23(30):3896-901
pubmed: 15917110
Geriatr Gerontol Int. 2012 Apr;12(2):223-9
pubmed: 21951819
Am J Med. 2013 Jul;126(7):615-24.e5
pubmed: 23499326
J Womens Health (Larchmt). 2020 Jul;29(7):927-936
pubmed: 32298606
J Am Med Dir Assoc. 2013 Jun;14(6):392-7
pubmed: 23764209
Immunotargets Ther. 2019 Aug 06;8:15-28
pubmed: 31497569
Adv Ther. 2013 Apr;30(4):387-405
pubmed: 23605248
Ageing Res Rev. 2020 Dec;64:101045
pubmed: 32171784
Clin Interv Aging. 2018 Aug 29;13:1497-1511
pubmed: 30214170
Lancet. 2019 Oct 12;394(10206):1365-1375
pubmed: 31609228
Infect Control Hosp Epidemiol. 2004 Nov;25(11):946-54
pubmed: 15566029
Intern Emerg Med. 2014 Mar;9(2):195-200
pubmed: 24048917
MMWR Morb Mortal Wkly Rep. 2019 Nov 22;68(46):1069-1075
pubmed: 31751323
Arch Gen Psychiatry. 2001 May;58(5):445-52
pubmed: 11343523
Aging Clin Exp Res. 2018 Jul;30(7):693-702
pubmed: 29721782
Nat Med. 2018 Jan 9;24(1):10-19
pubmed: 29315295
J Nutr Health Aging. 2004;8(1):28-37
pubmed: 14730365
Ageing Res Rev. 2018 Dec;48:145-152
pubmed: 30391341
Ageing Res Rev. 2020 Sep;62:101118
pubmed: 32565328
J Gerontol A Biol Sci Med Sci. 2019 Apr 23;74(5):659-666
pubmed: 29726918
Clin Vaccine Immunol. 2017 Mar 6;24(3):
pubmed: 28100496
JAMA Psychiatry. 2017 Mar 01;74(3):244-251
pubmed: 28114436
Aging Dis. 2018 Feb 1;9(1):151-164
pubmed: 29392090
Clin Microbiol Infect. 2019 Oct;25(10):1213-1225
pubmed: 31284031
Age Ageing. 2014 Nov;43(6):744-7
pubmed: 25336440
Aging Clin Exp Res. 2020 Jul;32(7):1199-1202
pubmed: 32390064
Neurosci Biobehav Rev. 2019 Dec;107:96-103
pubmed: 31491474
BMC Infect Dis. 2014 Oct 01;14:529
pubmed: 25273329
J Gerontol A Biol Sci Med Sci. 2001 Mar;56(3):M146-56
pubmed: 11253156
Hum Vaccin Immunother. 2018 Feb 1;14(2):361-367
pubmed: 29172948
Clin Infect Dis. 2009 Feb 15;48(4):443-8
pubmed: 19140756
J Infect Dis. 2016 Dec 15;214(12):1905-1910
pubmed: 27707807
J Clin Psychiatry. 2018 Jan/Feb;79(1):
pubmed: 29244265
JAMA. 2021 Mar 2;325(9):829-830
pubmed: 33512381
PLoS One. 2017 Jun 15;12(6):e0178383
pubmed: 28617837
BMJ. 2021 Feb 26;372:n513
pubmed: 33637577
N Engl J Med. 2001 Mar 22;344(12):889-96
pubmed: 11259722
Vaccine. 2019 Aug 14;37(35):5016-5024
pubmed: 31300288
Circ Res. 2018 Sep 14;123(7):740-744
pubmed: 30355074
Biogerontology. 2017 Aug;18(4):717-721
pubmed: 28220304
Prev Med. 2017 Aug;101:1-7
pubmed: 28533104
Age Ageing. 2020 Oct 23;49(6):923-926
pubmed: 32821901
Vaccine. 2017 Dec 14;35(49 Pt B):6828-6841
pubmed: 29146380
Vaccine. 2018 Jan 25;36(4):442-452
pubmed: 29287683
Vaccine. 2004 Jun 2;22(17-18):2298-306
pubmed: 15149789
Front Immunol. 2018 Oct 24;9:2465
pubmed: 30405641
Clin Infect Dis. 2009 Oct 1;49(7):1025-35
pubmed: 19708796
J Infect Dis. 2017 Aug 15;216(4):405-414
pubmed: 28931244
Science. 1996 Jul 5;273(5271):70-4
pubmed: 8658199
Mediators Inflamm. 2018 Jan 30;2018:7026198
pubmed: 29686533
Pathogens. 2019 Aug 13;8(3):
pubmed: 31412603
Exp Gerontol. 2014 Jun;54:90-3
pubmed: 24440387
J Leukoc Biol. 2018 Feb;103(2):321-339
pubmed: 28928269