LPS decreases CFTR open probability and mucociliary transport through generation of reactive oxygen species.

Animals Cystic Fibrosis Transmembrane Conductance Regulator Epithelial Cells / metabolism Humans Ion Transport Lipopolysaccharides Mucociliary Clearance Probability Reactive Oxygen Species
Chronic rhinosinusitis Cystic fibrosis transmembrane conductance regulator Lipopolysaccharide Micro optical coherence tomography Mucociliary transport Oxygen species Reactive

Journal

Redox biology
ISSN: 2213-2317
Titre abrégé: Redox Biol
Pays: Netherlands
ID NLM: 101605639

Informations de publication

Date de publication:
07 2021
Historique:
received: 23 04 2021
accepted: 26 04 2021
pubmed: 11 5 2021
medline: 6 7 2021
entrez: 10 5 2021
Statut: ppublish

Résumé

Lipopolysaccharide (LPS) serves as the interface between gram-negative bacteria (GNB) and the innate immune response in respiratory epithelial cells (REC). Herein, we describe a novel biological role of LPS that permits GNB to persist in the respiratory tract through inducing CFTR and mucociliary dysfunction. LPS reduced cystic fibrosis transmembrane conductance regulater (CFTR)-mediated short-circuit current in mammalian REC in Ussing chambers and nearly abrogated CFTR single channel activity (defined as forskolin-activated Cl

Identifiants

DOI: 10.1016/j.redox.2021.101998 PMID: 33971543 PMC: PMC8129928
pubmed: 33971543
pii: S2213-2317(21)00156-7
doi: 10.1016/j.redox.2021.101998
pmc: PMC8129928
pii:
doi:

Substances chimiques

CFTR protein, human 0
Lipopolysaccharides 0
Reactive Oxygen Species 0
Cystic Fibrosis Transmembrane Conductance Regulator 126880-72-6

Types de publication

Journal Article Research Support, N.I.H., Extramural

Langues

eng

Sous-ensembles de citation

IM

Pagination

101998

Subventions

Organisme : NIEHS NIH HHS
ID : R21 ES032956
Pays : United States
Organisme : NIDDK NIH HHS
ID : P30 DK072482
Pays : United States
Organisme : NIEHS NIH HHS
ID : U01 ES026458
Pays : United States
Organisme : NIAID NIH HHS
ID : K08 AI146220
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL133006
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL139876
Pays : United States

Informations de copyright

Copyright © 2021 The Authors. Published by Elsevier B.V. All rights reserved.

Auteurs

Do Yeon Cho (DY)

Department of Otolaryngology Head & Neck Surgery, University of Alabama at Birmingham, Birmingham, AL, USA; Gregory Fleming James Cystic Fibrosis Research Center, University of Alabama at Birmingham, Birmingham, AL, USA; Division of Otolaryngology, Department of Surgery, Veterans Affairs, Birmingham, AL, USA.

Shaoyan Zhang (S)

Department of Otolaryngology Head & Neck Surgery, University of Alabama at Birmingham, Birmingham, AL, USA; Gregory Fleming James Cystic Fibrosis Research Center, University of Alabama at Birmingham, Birmingham, AL, USA.

Ahmed Lazrak (A)

Gregory Fleming James Cystic Fibrosis Research Center, University of Alabama at Birmingham, Birmingham, AL, USA; Department of Anesthesiology, University of Alabama at Birmingham, Birmingham, AL, USA.

Daniel Skinner (D)

Department of Otolaryngology Head & Neck Surgery, University of Alabama at Birmingham, Birmingham, AL, USA; Gregory Fleming James Cystic Fibrosis Research Center, University of Alabama at Birmingham, Birmingham, AL, USA.

Harrison M Thompson (HM)

Department of Otolaryngology Head & Neck Surgery, University of Alabama at Birmingham, Birmingham, AL, USA.

Jessica Grayson (J)

Department of Otolaryngology Head & Neck Surgery, University of Alabama at Birmingham, Birmingham, AL, USA.

Purushotham Guroji (P)

Department of Cell Developmental and Integrative Biology, University of Alabama at Birmingham, Birmingham, AL, USA.

Saurabh Aggarwal (S)

Gregory Fleming James Cystic Fibrosis Research Center, University of Alabama at Birmingham, Birmingham, AL, USA; Department of Anesthesiology, University of Alabama at Birmingham, Birmingham, AL, USA.

Zsuzsanna Bebok (Z)

Gregory Fleming James Cystic Fibrosis Research Center, University of Alabama at Birmingham, Birmingham, AL, USA; Department of Cell Developmental and Integrative Biology, University of Alabama at Birmingham, Birmingham, AL, USA.

Steven M Rowe (SM)

Gregory Fleming James Cystic Fibrosis Research Center, University of Alabama at Birmingham, Birmingham, AL, USA; Department of Cell Developmental and Integrative Biology, University of Alabama at Birmingham, Birmingham, AL, USA; Department of Pediatrics, University of Alabama at Birmingham, Birmingham, AL, USA; Department of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA.

Sadis Matalon (S)

Gregory Fleming James Cystic Fibrosis Research Center, University of Alabama at Birmingham, Birmingham, AL, USA; Department of Anesthesiology, University of Alabama at Birmingham, Birmingham, AL, USA.

Eric J Sorscher (EJ)

Department of Pediatrics, Emory University, Atlanta, GA, USA.

Bradford A Woodworth (BA)

Department of Otolaryngology Head & Neck Surgery, University of Alabama at Birmingham, Birmingham, AL, USA; Gregory Fleming James Cystic Fibrosis Research Center, University of Alabama at Birmingham, Birmingham, AL, USA. Electronic address: bwoodworth@uabmc.edu.

Articles similaires

[Redispensing of expensive oral anticancer medicines: a practical application].

Lisanne N van Merendonk, Kübra Akgöl, Bastiaan Nuijen
1.00
Humans Antineoplastic Agents Administration, Oral Drug Costs Counterfeit Drugs

Smoking Cessation and Incident Cardiovascular Disease.

Jun Hwan Cho, Seung Yong Shin, Hoseob Kim et al.
1.00
Humans Male Smoking Cessation Cardiovascular Diseases Female

Evaluation of Low-Value Services Across Major Medicare Advantage Insurers and Traditional Medicare.

Ciara Duggan, Adam L Beckman, Ishani Ganguli et al.
1.00
Humans United States Aged Cross-Sectional Studies Medicare Part C

Effectiveness of Virtual Yoga for Chronic Low Back Pain: A Randomized Clinical Trial.

Hallie Tankha, Devyn Gaskins, Amanda Shallcross et al.
1.00
Humans Yoga Low Back Pain Female Male

Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › LPS decreases CFTR open probability and...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Protéines de transport membranaire › Pompes ioniques › Transporteurs d'anions › Transporteurs d'anions organiques › Transporteurs d'anions organiques ATP-dépendants › Protéines associées à la multirésistance aux médicaments › Protéine CFTR › LPS decreases CFTR open probability and...
questionsmedicales.fr › Cellules › Cellules épithéliales › LPS decreases CFTR open probability and...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › LPS decreases CFTR open probability and...
questionsmedicales.fr › Métabolisme › Transport biologique › Transport des ions › LPS decreases CFTR open probability and...
questionsmedicales.fr › Facteurs biologiques › Toxines biologiques › Toxines bactériennes › Endotoxines › Lipopolysaccharides › LPS decreases CFTR open probability and...
questionsmedicales.fr › Phénomènes physiologiques respiratoires et circulatoires › Phénomènes physiologiques respiratoires › Clairance mucociliaire › LPS decreases CFTR open probability and...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Statistiques comme sujet › Probabilité › LPS decreases CFTR open probability and...
questionsmedicales.fr › Produits chimiques inorganiques › Composés de l'oxygène › Espèces réactives de l'oxygène › LPS decreases CFTR open probability and...