Discovery of Candidate DNA Methylation Cancer Driver Genes.
Journal
Cancer discovery
ISSN: 2159-8290
Titre abrégé: Cancer Discov
Pays: United States
ID NLM: 101561693
Informations de publication
Date de publication:
09 2021
09 2021
Historique:
received:
17
09
2020
revised:
25
02
2021
accepted:
15
04
2021
pubmed:
12
5
2021
medline:
1
4
2022
entrez:
11
5
2021
Statut:
ppublish
Résumé
Epigenetic alterations, such as promoter hypermethylation, may drive cancer through tumor suppressor gene inactivation. However, we have limited ability to differentiate driver DNA methylation (DNAme) changes from passenger events. We developed DNAme driver inference-MethSig-accounting for the varying stochastic hypermethylation rate across the genome and between samples. We applied MethSig to bisulfite sequencing data of chronic lymphocytic leukemia (CLL), multiple myeloma, ductal carcinoma
Identifiants
pubmed: 33972312
pii: 2159-8290.CD-20-1334
doi: 10.1158/2159-8290.CD-20-1334
pmc: PMC8419066
mid: NIHMS1700591
doi:
Types de publication
Journal Article
Randomized Controlled Trial
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
2266-2281Subventions
Organisme : NCI NIH HHS
ID : DP2 CA239065
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA229902
Pays : United States
Informations de copyright
©2021 American Association for Cancer Research.
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