TSG101 negatively regulates mitochondrial biogenesis in axons.
Animals
Animals, Genetically Modified
Axons
/ metabolism
Cytoskeletal Proteins
/ genetics
DNA-Binding Proteins
/ genetics
Drosophila Proteins
/ genetics
Drosophila melanogaster
/ genetics
Endosomal Sorting Complexes Required for Transport
/ genetics
Female
GTP-Binding Proteins
/ genetics
Humans
Male
Mitochondria
/ genetics
Mitochondrial Dynamics
/ genetics
Mitophagy
/ genetics
Mutation
NF-E2-Related Factor 2
/ genetics
Neurons
/ cytology
Organelle Biogenesis
Transcription Factors
/ genetics
ESCRT
TSG101
mitochondria
mitochondrial biogenesis
neurodegeneration
Journal
Proceedings of the National Academy of Sciences of the United States of America
ISSN: 1091-6490
Titre abrégé: Proc Natl Acad Sci U S A
Pays: United States
ID NLM: 7505876
Informations de publication
Date de publication:
18 05 2021
18 05 2021
Historique:
entrez:
11
5
2021
pubmed:
12
5
2021
medline:
15
12
2021
Statut:
ppublish
Résumé
There is a tight association between mitochondrial dysfunction and neurodegenerative diseases and axons that are particularly vulnerable to degeneration, but how mitochondria are maintained in axons to support their physiology remains poorly defined. In an in vivo forward genetic screen for mutants altering axonal mitochondria, we identified
Identifiants
pubmed: 33972422
pii: 2018770118
doi: 10.1073/pnas.2018770118
pmc: PMC8157921
pii:
doi:
Substances chimiques
Cytoskeletal Proteins
0
DNA-Binding Proteins
0
Drosophila Proteins
0
Endosomal Sorting Complexes Required for Transport
0
NF-E2-Related Factor 2
0
Transcription Factors
0
Tsg101 protein
0
DRP1 protein, Drosophila
EC 3.6.1.-
GTP-Binding Proteins
EC 3.6.1.-
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Medical Research Council
ID : MC_PC_16030/1
Pays : United Kingdom
Organisme : NINDS NIH HHS
ID : R01 NS059991
Pays : United States
Organisme : NINDS NIH HHS
ID : R21 NS098364
Pays : United States
Informations de copyright
Copyright © 2021 the Author(s). Published by PNAS.
Déclaration de conflit d'intérêts
The authors declare no competing interest.
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