Serotonin transporter availability increases in patients recovering from a depressive episode.


Journal

Translational psychiatry
ISSN: 2158-3188
Titre abrégé: Transl Psychiatry
Pays: United States
ID NLM: 101562664

Informations de publication

Date de publication:
10 05 2021
Historique:
received: 18 03 2021
accepted: 13 04 2021
revised: 24 03 2021
entrez: 11 5 2021
pubmed: 12 5 2021
medline: 29 6 2021
Statut: epublish

Résumé

Molecular imaging studies have shown low cerebral concentration of serotonin transporter in patients suffering from depression, compared to healthy control subjects. Whether or not this difference also is present before disease onset and after remission (i.e. a trait), or only at the time of the depressive episode (i.e. a state) remains to be explored. We examined 17 patients with major depressive disorder with positron emission tomography using [

Identifiants

pubmed: 33972499
doi: 10.1038/s41398-021-01376-w
pii: 10.1038/s41398-021-01376-w
pmc: PMC8110529
doi:

Substances chimiques

Serotonin Plasma Membrane Transport Proteins 0

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

264

Subventions

Organisme : Vetenskapsrådet (Swedish Research Council)
ID : 2013-09304

Références

World Health Organization. Depression and Other Common Mental Disorders: Global Health Estimates (WHO, 2017).
Hirschfeld, R. M. History and evolution of the monoamine hypothesis of depression. J. Clin. Psychiatry 61, 4–6 (2000).
Asberg, M., Träskman, L. & Thorén, P. 5-HIAA in the Cerebrospinal Fluid. Arch. Gen. Psychiatry 33, 1193–1197 (1976).
doi: 10.1001/archpsyc.1976.01770100055005
Delgado, P. Serotonin function and the mechanism of antidepressant action. Reversal of antidepressant-induced remission by rapid depletion of plasma tryptophan. Arch. Gen. Psychiatry 47, 411–418 (1990).
doi: 10.1001/archpsyc.1990.01810170011002
Smith, K. A., Fairburn, C. G. & Cowen, P. J. Relapse of depression after rapid depletion of tryptophan. Lancet 349, 915–919 (1997).
doi: 10.1016/S0140-6736(96)07044-4
Warden, D., Rush, A., Trivedi, M., Fava, M. & Wisniewski, S. The STAR*D Project results: a comprehensive review of findings. Curr. Psychiatry Rep. 9, 449–459 (2008).
doi: 10.1007/s11920-007-0061-3
Coppen, A. The biochemistry of affective disorders. Br. J. Psychiatry 113, 1237–1264 (1967).
doi: 10.1192/bjp.113.504.1237
Carhart-Harris, R. L. & Nutt, D. J. Serotonin and brain function: a tale of two receptors. J. Psychopharmacol. 31, 1091–1120 (2017).
doi: 10.1177/0269881117725915
Cowen, P. J. & Browning, M. What has serotonin to do with depression? World Psychiatry 14, 158–160 (2015).
doi: 10.1002/wps.20229
Flory, J. D., Mann, J. J., Manuck, S. B. & Muldoon, M. F. Recovery from major depression is not associated with normalization of serotonergic function. Biol. Psychiatry 43, 320–326 (1998).
doi: 10.1016/S0006-3223(97)00480-0
Ressler, K. J. & Nemeroff, C. B. Role of serotonergic and noradrenergic systems in the pathophysiology of depression and anxiety disorders. Depress. Anxiety 12, 2–19 (2000).
doi: 10.1002/1520-6394(2000)12:1+<2::AID-DA2>3.0.CO;2-4
Charnay, Y. & Léger, L. Brain serotonergic circuitries. Dialogues Clin. Neurosci. 12, 471–487 (2010).
doi: 10.31887/DCNS.2010.12.4/ycharnay
Grohol, J. Top 25 psychiatric medications for 2018. PsychCentral https://psychcentral.com/blog/top-25-psychiatric-medications-for-2018/ (2019).
Parsey, R. V. et al. Lower serotonin transporter binding potential in the human brain during major depressive episodes. Am. J. Psychiatry 163, 52–58 (2006).
doi: 10.1176/appi.ajp.163.1.52
Selvaraj, S. et al. Diminished brain 5-HT transporter binding in major depression: a positron emission tomography study with [11C]DASB. Psychopharmacology 213, 555–562 (2011).
doi: 10.1007/s00213-009-1660-y
Yeh, Y.-W. et al. Incongruent reduction of serotonin transporter associated with suicide attempts in patients with major depressive disorder: a positron emission tomography study with 4-[18F]-ADAM. Int. J. Neuropsychopharmacol. 18, pyu065 (2014).
Reimold, M. et al. Anxiety is associated with reduced central serotonin transporter availability in unmedicated patients with unipolar major depression: a [11C]DASB PET study. Mol. Psychiatry 13, 606–613 (2008).
doi: 10.1038/sj.mp.4002149
Cannon, D. M. et al. Elevated serotonin transporter binding in major depressive disorder assessed using positron emission tomography and [11C]DASB; comparison with bipolar disorder. Biol. Psychiatry 62, 870–877 (2007).
doi: 10.1016/j.biopsych.2007.03.016
Gryglewski, G., Lanzenberger, R., Kranz, G. S. & Cumming, P. Meta-analysis of molecular imaging of serotonin transporters in major depression. J. Cereb. Blood Flow Metab. 34, 1096–1103 (2014).
doi: 10.1038/jcbfm.2014.82
Spies, M., Knudsen, G. M., Lanzenberger, R. & Kasper, S. The serotonin transporter in psychiatric disorders: insights from PET imaging. Lancet Psychiatry 2, 743–755 (2015).
doi: 10.1016/S2215-0366(15)00232-1
Varnäs, K., Halldin, C. & Hall, H. Autoradiographic distribution of serotonin transporters and receptor subtypes in human brain. Hum. Brain Mapp. 22, 246–260 (2004).
doi: 10.1002/hbm.20035
Vertes, R. P. & Linley, S. B. in Efferent And Afferent Connections of The Dorsal and Median Raphe Nuclei in The Rat BT - Serotonin and Sleep: Molecular, Functional and Clinical Aspects (eds. Monti, J. M., Pandi-Perumal, S. R., Jacobs, B. L. & Nutt, D. J.) 69–102 (Birkhäuser Basel, 2008).
Lanzenberger, R. et al. Prediction of SSRI treatment response in major depression based on serotonin transporter interplay between median raphe nucleus and projection areas. Neuroimage 63, 874–881 (2012).
doi: 10.1016/j.neuroimage.2012.07.023
Deakin, J. F. W. Depression and antisocial personality disorder: two contrasting disorders of 5HT function. Neuropsychopharmacology 64, 79–93 (2003).
doi: 10.1007/978-3-7091-6020-6_5
Weitz, E. S. et al. Baseline depression severity as moderator of depression outcomes between cognitive behavioral therapy vs pharmacotherapy: an individual patient data meta-analysis. JAMA Psychiatry 72, 1102–1109 (2015).
doi: 10.1001/jamapsychiatry.2015.1516
Carlbring, P., Andersson, G., Cuijpers, P., Riper, H. & Hedman-Lagerlöf, E. Internet-based vs. face-to-face cognitive behavior therapy for psychiatric and somatic disorders: an updated systematic review and meta-analysis. Cogn. Behav. Ther. 47, 1–18 (2018).
doi: 10.1080/16506073.2017.1401115
Titov, N. et al. ICBT in routine care: a descriptive analysis of successful clinics in five countries. Internet Interv. 13, 108–115 (2018).
doi: 10.1016/j.invent.2018.07.006
Lundberg, J., Halldin, C. & Farde, L. Measurement of serotonin transporter binding with PET and [11C]MADAM: A test–retest reproducibility study. Synapse 60, 256–263 (2006).
doi: 10.1002/syn.20297
Sheehan, D. V. et al. The Mini-International Neuropsychiatric Interview (M.I.N.I.): The development and validation of a structured diagnostic psychiatric interview for DSM-IV and ICD-10. J. Clin. Psychiatry 59, 22–33 (1998).
American Psychiatric Association. Diagnostic and Statistical Manual of Mental Disorders, 4th edn (DSM-4) (American Psychiatric Press, 1994).
Montgomery, S. A. & Åsberg, M. A new depression scale designed to be sensitive to change. Br. J. Psychiatry 134, 382–389 (1979).
doi: 10.1192/bjp.134.4.382
Svanborg, P. & Åsberg, M. A new self-rating scale for depression and anxiety states based on the Comprehensive Psychopathological Rating Scale. Acta Psychiatr. Scand. 89, 21–28 (1994).
doi: 10.1111/j.1600-0447.1994.tb01480.x
Andersson, G. et al. Internet-based self-help for depression: randomised controlled trial. Br. J. Psychiatry 187, 456–61 (2005).
Hedman, E. et al. Effectiveness of Internet-based cognitive behaviour therapy for depression in routine psychiatric care. J. Affect. Disord. 155, 49–58 (2014).
doi: 10.1016/j.jad.2013.10.023
Varrone, A. et al. Advancement in PET quantification using 3D-OP-OSEM point spread function reconstruction with the HRRT. Eur. J. Nucl. Med. Mol. Imaging 36, 1639–1650 (2009).
doi: 10.1007/s00259-009-1156-3
Halldin, C. et al. [11C]MADAM, a new serotonin transporter radioligand characterized in the monkey brain by PET. Synapse 58, 173–183 (2005).
doi: 10.1002/syn.20189
Lundberg, J., Odano, I., Olsson, H., Halldin, C. & Farde, L. Quantification of 11C-MADAM binding to the serotonin transporter in the human brain. J. Nucl. Med. 46, 1505–1515 (2005).
Matheson, G. J. et al. Reliability of volumetric and surface-based normalisation and smoothing techniques for PET analysis of the cortex: a test-retest analysis using [11C]SCH-23390. Neuroimage 155, 344–353 (2017).
doi: 10.1016/j.neuroimage.2017.04.031
Nørgaard, M. et al. Optimization of preprocessing strategies in Positron Emission Tomography (PET) neuroimaging: A [11C]DASB PET study. Neuroimage 199, 466–479 (2019).
doi: 10.1016/j.neuroimage.2019.05.055
Lammertsma, A. A. & Hume, S. P. Simplified reference tissue model for PET receptor studies. Neuroimage 4, 153–158 (1996).
doi: 10.1006/nimg.1996.0066
Svensson, J. E. et al. Validity and reliability of extrastriatal [11C]raclopride binding quantification in the living human brain. Neuroimage 202, 116143 (2019).
doi: 10.1016/j.neuroimage.2019.116143
Ganz, M. et al. Cerebellar heterogeneity and its impact on PET data quantification of 5-HT receptor radioligands. J. Cereb. Blood Flow. Metab. 37, 3243–3252 (2017).
doi: 10.1177/0271678X16686092
Cselényi, Z., Olsson, H., Farde, L. & Gulyás, B. Wavelet-aided parametric mapping of cerebral dopamine D2 receptors using the high affinity PET radioligand [11C]FLB 457. Neuroimage 17, 47–60 (2002).
doi: 10.1006/nimg.2002.1152
Schain, M. et al. Improved mapping and quantification of serotonin transporter availability in the human brainstem with the HRRT. Eur. J. Nucl. Med. Mol. Imaging 40, 228–237 (2013).
doi: 10.1007/s00259-012-2260-3
Evans, A. C. et al. 3D statistical neuroanatomical models from 305 MRI volumes. in 1993 IEEE Conference Record Nuclear Science Symposium and Medical Imaging Conference. 1813–1817 vol. 3 (IEEE, 1993).
Fischl, B. FreeSurfer. Neuroimage 62, 774–781 (2012).
doi: 10.1016/j.neuroimage.2012.01.021
Beliveau, V. et al. The structure of the serotonin system: A PET imaging study. Neuroimage 205, 116240 (2020).
doi: 10.1016/j.neuroimage.2019.116240
Miller, J. M. et al. Positron emission tomography quantification of serotonin transporter in suicide attempters with major depressive disorder. Biol. Psychiatry 74, 287–295 (2013).
doi: 10.1016/j.biopsych.2013.01.024
Beliveau, V. et al. Functional connectivity of the dorsal and median raphe nuclei at rest. Neuroimage 116, 187–195 (2015).
doi: 10.1016/j.neuroimage.2015.04.065
Knudsen, G. M. et al. Guidelines for the content and format of PET brain data in publications and archives: a consensus paper. J. Cereb. Blood Flow Metab. https://doi.org/10.1177/0271678X20905433 (2020).
Lakens, D. Calculating and reporting effect sizes to facilitate cumulative science: a practical primer for t-tests and ANOVAs. Front. Psychol. 4, 1–12 (2013).
doi: 10.3389/fpsyg.2013.00863
Finnema, S. J. et al. Application of cross-species PET imaging to assess neurotransmitter release in brain. Psychopharmacology 232, 4129–4157 (2015).
doi: 10.1007/s00213-015-3938-6
Duman, R. S., Aghajanian, G. K., Sanacora, G. & Krystal, J. H. Synaptic plasticity and depression: new insights from stress and rapid-acting antidepressants. Nat. Med. 22, 238–249 (2016).
doi: 10.1038/nm.4050
Chen, F., Danladi, J., Wegener, G., Madsen, T. M. & Nyengaard, J. R. Sustained ultrastructural changes in rat hippocampal formation after repeated electroconvulsive seizures. Int. J. Neuropsychopharmacol. https://doi.org/10.1093/ijnp/pyaa021 (2020).
Holmes, S. E. et al. Lower synaptic density is associated with depression severity and network alterations. Nat. Commun. 10, 1529 (2019).
doi: 10.1038/s41467-019-09562-7
Tiger, M., Varnäs, K., Okubo, Y. & Lundberg, J. The 5-HT(1B) receptor-a potential target for antidepressant treatment. Psychopharmacology 235, 1317–1334 (2018).
doi: 10.1007/s00213-018-4872-1
Savitz, J. B. & Drevets, W. C. Neuroreceptor imaging in depression. Neurobiol. Dis. 52, 49–65 (2013).
doi: 10.1016/j.nbd.2012.06.001
Mc Mahon, B. et al. Seasonality-resilient individuals downregulate their cerebral 5-HT transporter binding in winter – a longitudinal combined 11C-DASB and 11C-SB207145 PET study. Eur. Neuropsychopharmacol. 28, 1151–1160 (2018).
doi: 10.1016/j.euroneuro.2018.06.004
Reisinger, S. N., Wanek, T., Langer, O. & Pollak, D. D. PET imaging of the mouse brain reveals a dynamic regulation of SERT density in a chronic stress model. Transl. Psychiatry 9, 80 (2019).
doi: 10.1038/s41398-019-0416-7
Kim, J. S., Ichise, M., Sangare, J. & Innis, R. B. PET imaging of serotonin transporters with [11C]DASB: test–retest reproducibility using a multilinear reference tissue parametric imaging method. J. Nucl. Med. 47, 208–214 (2006).
Frankle, W. G. et al. Estimation of serotonin transporter parameters with 11C-DASB in healthy humans: reproducibility and comparison of methods. J. Nucl. Med. 47, 815–826 (2006).
Meyer, J. H. et al. Occupancy of serotonin transporters by paroxetine and citalopram during treatment of depression: a [11C]DASB PET Imaging Study. Am. J. Psychiatry 158, 1843–1849 (2001).
doi: 10.1176/appi.ajp.158.11.1843
Praschak-rieder, N. et al. Effects of tryptophan depletion on the serotonin transporter in healthy humans. Biol. Psychiatry https://doi.org/10.1016/j.biopsych.2005.04.038 (2005).
Ogden, R. T. et al. In vivo quantification of serotonin transporters using [(11)C]DASB and positron emission tomography in humans: modeling considerations. J. Cereb. Blood Flow. Metab. 27, 205–217 (2007).
doi: 10.1038/sj.jcbfm.9600329

Auteurs

Jonas E Svensson (JE)

Centre for Psychiatry Research, Department of Clinical Neuroscience, Karolinska Institutet, & Stockholm Health Care Services, Region Stockholm, Karolinska University Hospital, SE-171 76, Stockholm, Sweden. Jonas.svensson@ki.se.

Cecilia Svanborg (C)

Centre for Psychiatry Research, Department of Clinical Neuroscience, Karolinska Institutet, & Stockholm Health Care Services, Region Stockholm, Karolinska University Hospital, SE-171 76, Stockholm, Sweden.

Pontus Plavén-Sigray (P)

Centre for Psychiatry Research, Department of Clinical Neuroscience, Karolinska Institutet, & Stockholm Health Care Services, Region Stockholm, Karolinska University Hospital, SE-171 76, Stockholm, Sweden.
Neurobiology Research Unit, Copenhagen University Hospital, Copenhagen, Denmark.

Viktor Kaldo (V)

Centre for Psychiatry Research, Department of Clinical Neuroscience, Karolinska Institutet, & Stockholm Health Care Services, Region Stockholm, Karolinska University Hospital, SE-171 76, Stockholm, Sweden.
Department of Psychology, Faculty of Health and Life Sciences, Linnaeus University, Växjö, Sweden.

Christer Halldin (C)

Centre for Psychiatry Research, Department of Clinical Neuroscience, Karolinska Institutet, & Stockholm Health Care Services, Region Stockholm, Karolinska University Hospital, SE-171 76, Stockholm, Sweden.

Martin Schain (M)

Neurobiology Research Unit, Copenhagen University Hospital, Copenhagen, Denmark.

Johan Lundberg (J)

Centre for Psychiatry Research, Department of Clinical Neuroscience, Karolinska Institutet, & Stockholm Health Care Services, Region Stockholm, Karolinska University Hospital, SE-171 76, Stockholm, Sweden.

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