Preserved structural connectivity mediates the clinical effect of thrombolysis in patients with anterior-circulation stroke.
Aged
Brain
/ diagnostic imaging
Brain Ischemia
/ diagnostic imaging
Disease Progression
Fibrinolytic Agents
/ therapeutic use
Humans
Magnetic Resonance Imaging
Middle Aged
Nerve Net
/ drug effects
Randomized Controlled Trials as Topic
Severity of Illness Index
Stroke
/ physiopathology
Thrombolytic Therapy
/ adverse effects
Time Factors
Tissue Plasminogen Activator
/ therapeutic use
Journal
Nature communications
ISSN: 2041-1723
Titre abrégé: Nat Commun
Pays: England
ID NLM: 101528555
Informations de publication
Date de publication:
10 05 2021
10 05 2021
Historique:
received:
21
01
2020
accepted:
29
03
2021
entrez:
11
5
2021
pubmed:
12
5
2021
medline:
3
6
2021
Statut:
epublish
Résumé
Thrombolysis with recombinant tissue plasminogen activator in acute ischemic stroke aims to restore compromised blood flow and prevent further neuronal damage. Despite the proven clinical efficacy of this treatment, little is known about the short-term effects of systemic thrombolysis on structural brain connectivity. In this secondary analysis of the WAKE-UP trial, we used MRI-derived measures of infarct size and estimated structural network disruption to establish that thrombolysis is associated not only with less infarct growth, but also with reduced loss of large-scale connectivity between grey-matter areas after stroke. In a causal mediation analysis, infarct growth mediated a non-significant 8.3% (CI
Identifiants
pubmed: 33972513
doi: 10.1038/s41467-021-22786-w
pii: 10.1038/s41467-021-22786-w
pmc: PMC8110812
doi:
Substances chimiques
Fibrinolytic Agents
0
Tissue Plasminogen Activator
EC 3.4.21.68
Types de publication
Clinical Trial
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
2590Subventions
Organisme : Medical Research Council
ID : MR/N003403/1
Pays : United Kingdom
Références
Brain Commun. 2019 Oct 04;1(1):fcz020
pubmed: 32954263
Neuroimage. 2002 Jan;15(1):273-89
pubmed: 11771995
Stroke. 2017 May;48(5):1233-1240
pubmed: 28351963
Hum Brain Mapp. 2013 Nov;34(11):2747-66
pubmed: 22611035
Neuroimage. 2006 Jul 1;31(3):968-80
pubmed: 16530430
Stroke. 2007 Nov;38(11):2919-23
pubmed: 17901392
Neurology. 2020 Mar 31;94(13):571-587
pubmed: 32132175
Stroke. 2020 Jan;51(1):209-215
pubmed: 31662118
Neuroimage Clin. 2019;23:101852
pubmed: 31077981
Hum Brain Mapp. 2009 Oct;30(10):3127-41
pubmed: 19235882
Biometrics. 2015 Mar;71(1):1-14
pubmed: 25351114
Lancet Neurol. 2011 Nov;10(11):978-86
pubmed: 21978972
Eur Neuropsychopharmacol. 2010 Aug;20(8):519-34
pubmed: 20471808
Acta Neurochir Suppl. 2004;89:55-61
pubmed: 15335101
N Engl J Med. 2018 Feb 22;378(8):708-718
pubmed: 29364767
Stroke. 2014 Nov;45(11):3275-9
pubmed: 25213340
Cell Rep. 2019 Sep 3;28(10):2527-2540.e9
pubmed: 31484066
Stroke. 2017 Jul;48(7):2007-2012
pubmed: 28626052
Stroke. 2006 May;37(5):1211-6
pubmed: 16574931
Neuroimage Clin. 2013 May 27;2:767-81
pubmed: 24179827
Neuroimage. 2008 May 15;41(1):58-68
pubmed: 18367409
N Engl J Med. 2018 Aug 16;379(7):611-622
pubmed: 29766770
NMR Biomed. 2019 Apr;32(4):e3785
pubmed: 28945294
Am J Epidemiol. 2010 Dec 15;172(12):1339-48
pubmed: 21036955
Stroke. 2007 Jan;38(1):194-7
pubmed: 17122428
Lancet. 2012 Jun 23;379(9834):2352-63
pubmed: 22632908
Annu Rev Public Health. 2016;37:17-32
pubmed: 26653405
Radiology. 2018 Aug;288(2):573-581
pubmed: 29762091
Neurology. 2014 Jul 29;83(5):398-405
pubmed: 24966405
Arch Neurol. 2001 Apr;58(4):613-7
pubmed: 11295992
Brain. 2020 Jul 1;143(7):2173-2188
pubmed: 32572442
Methods Inf Med. 2014;53(6):469-81
pubmed: 25301390
J Cereb Blood Flow Metab. 2015 Sep;35(9):1507-14
pubmed: 25920957
Am J Epidemiol. 2017 Jul 15;186(2):184-193
pubmed: 28472328
Neuroimage. 2014 Oct 15;100:684-691
pubmed: 24999038
Stroke. 2009 Apr;40(4):1353-8
pubmed: 19246703
Health Psychol. 2008 Mar;27(2S):S101-8
pubmed: 18377151
Neurology. 2018 Nov 27;91(22):e2067-e2077
pubmed: 30366975
Brain Commun. 2020 Jan 10;2(1):fcaa001
pubmed: 32954275
Q J Exp Psychol (Hove). 2016 Jun;69(6):1243-1244
pubmed: 28190383
Hum Brain Mapp. 2015 Jun;36(6):2147-60
pubmed: 25655204
N Engl J Med. 1995 Dec 14;333(24):1581-7
pubmed: 7477192
Brain Connect. 2013;3(5):451-63
pubmed: 23855491
Gigascience. 2018 Mar 1;7(3):1-17
pubmed: 29432527
Stroke. 2000 Dec;31(12):2912-9
pubmed: 11108748
Stroke. 2014 Jun;45(6):1695-702
pubmed: 24781084
Hum Brain Mapp. 2016 Jul;37(7):2587-601
pubmed: 27016287
JAMA Neurol. 2019 Feb 1;76(2):194-202
pubmed: 30615038
Stroke. 2014 Mar;45(3):717-22
pubmed: 24523041
Stroke. 2003 Mar;34(3):806-12
pubmed: 12624314
Brain. 2015 Oct;138(Pt 10):3061-75
pubmed: 26264514
Stroke. 1996 Apr;27(4):761-5
pubmed: 8614945