Hunger or thirst state uncertainty is resolved by outcome evaluation in medial prefrontal cortex to guide decision-making.
Journal
Nature neuroscience
ISSN: 1546-1726
Titre abrégé: Nat Neurosci
Pays: United States
ID NLM: 9809671
Informations de publication
Date de publication:
07 2021
07 2021
Historique:
received:
09
01
2021
accepted:
26
03
2021
pubmed:
12
5
2021
medline:
18
9
2021
entrez:
11
5
2021
Statut:
ppublish
Résumé
Physiological need states direct decision-making toward re-establishing homeostasis. Using a two-alternative forced choice task for mice that models elements of human decisions, we found that varying hunger and thirst states caused need-inappropriate choices, such as food seeking when thirsty. These results show limits on interoceptive knowledge of hunger and thirst states to guide decision-making. Instead, need states were identified after food and water consumption by outcome evaluation, which depended on the medial prefrontal cortex.
Identifiants
pubmed: 33972802
doi: 10.1038/s41593-021-00850-4
pii: 10.1038/s41593-021-00850-4
pmc: PMC8254795
mid: NIHMS1688147
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
907-912Subventions
Organisme : Howard Hughes Medical Institute
Pays : United States
Organisme : Wellcome Trust
ID : 204717/Z/16/Z
Pays : United Kingdom
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