The Efficacy of Herbal Supplements and Nutraceuticals for Prevention of Migraine: Can They Help?
antioxidants
coenzyme q10
headache
herbal supplements
migraine
nutraceuticals
prevention
riboflavin
Journal
Cureus
ISSN: 2168-8184
Titre abrégé: Cureus
Pays: United States
ID NLM: 101596737
Informations de publication
Date de publication:
06 May 2021
06 May 2021
Historique:
entrez:
11
5
2021
pubmed:
12
5
2021
medline:
12
5
2021
Statut:
epublish
Résumé
Migraine is a common neurological disorder associated with or without aura. Although the pathophysiology of migraine is not very well understood, pro-inflammatory cytokines and oxidative stress biomarkers are found to be increased in migraine. Multiple studies have been done to see if alternative medicine such as herbal supplements and nutraceuticals are effective in the prevention and treatment of migraine headaches. This review aimed to evaluate the effect of supplements like coenzyme Q10, riboflavin (vitamin B2), feverfew, and magnesium on the frequency, severity, and duration of migraine attacks. We performed a thorough literature search using mainly PubMed. We included studies published in the last 10 years, those conducted among adult human participants 18-65 years of age, and those published in the English language. Based on the articles selected for the final review, we concluded that herbal supplements and nutraceuticals help reduce the frequency of migraine headaches; however, mixed results were seen regarding the severity and duration of headaches. Moreover, there were no concerning side effects with these supplements. Therefore, physicians can suggest herbal supplements to patients who experience adverse effects from pharmaceutical drugs and desire a more natural treatment.
Identifiants
pubmed: 33972917
doi: 10.7759/cureus.14868
pmc: PMC8105190
doi:
Types de publication
Journal Article
Review
Langues
eng
Pagination
e14868Informations de copyright
Copyright © 2021, Kaur et al.
Déclaration de conflit d'intérêts
The authors have declared that no competing interests exist.
Références
Neurol Clin. 2019 Nov;37(4):631-649
pubmed: 31563224
Cephalalgia. 2019 Apr;39(5):648-654
pubmed: 30612463
Headache. 2015 Jan;55(1):35-54
pubmed: 25546573
Neuropsychiatr Dis Treat. 2018 Jan 24;14:367-374
pubmed: 29416338
J Headache Pain. 2019 Jun 21;20(1):72
pubmed: 31226929
Headache. 2003 May;43(5):490-5
pubmed: 12752755
Nutr Neurosci. 2021 Apr;24(4):317-326
pubmed: 31241007
Pharmacogn Rev. 2011 Jan;5(9):103-10
pubmed: 22096324
Int J Mol Sci. 2014 Nov 05;15(11):20169-208
pubmed: 25380523
Neurotherapeutics. 2018 Apr;15(2):313-323
pubmed: 29671241
Vision (Basel). 2018 Feb 09;2(1):
pubmed: 31735871
Headache. 2014 Nov-Dec;54(10):1670-9
pubmed: 25399858
N Engl J Med. 2004 Mar 11;350(11):1073-5
pubmed: 15014178
BMC Complement Altern Med. 2017 Aug 30;17(1):433
pubmed: 28854909
Lancet. 2015 Aug 22;386(9995):743-800
pubmed: 26063472
Nat Genet. 2003 Feb;33(2):192-6
pubmed: 12539047
Headache. 2016 Apr;56(4):808-16
pubmed: 26954394
J Pediatr. 2012 Aug;161(2):308-13.e1
pubmed: 22381023
Cephalalgia. 1997 Aug;17(5):580-4
pubmed: 9251872
Cephalalgia. 2009 Jul;29(7):719-28
pubmed: 19220304
Headache. 2015 Jan;55(1):21-34
pubmed: 25600719
Curr Pain Headache Rep. 2014 Oct;18(10):454
pubmed: 25160711
Aust Fam Physician. 2011 Sep;40(9):684-90
pubmed: 21894275
J Headache Pain. 2015;16:516
pubmed: 25916335
Curr Treat Options Neurol. 2016 Apr;18(4):14
pubmed: 26923604
Acta Neurol Belg. 2017 Mar;117(1):103-109
pubmed: 27670440
Cell. 1996 Nov 1;87(3):543-52
pubmed: 8898206
Eur Rev Med Pharmacol Sci. 2010 Oct;14(10):877-82
pubmed: 21222375
J Headache Pain. 2016;17:10
pubmed: 26883365
Mol Syndromol. 2014 Jul;5(3-4):187-97
pubmed: 25126052
Cephalalgia. 2013 Jun;33(8):614-25
pubmed: 23671257
J Headache Pain. 2015 Dec;16(Suppl 1):A139
pubmed: 28132249
J Headache Pain. 2015 Dec;16(Suppl 1):A186
pubmed: 28132202
J Pharmacol Sci. 2009 Jul;110(3):362-9
pubmed: 19609067
Nutr Neurosci. 2020 Nov;23(11):868-875
pubmed: 30727862
J Clin Med. 2020 Dec 27;10(1):
pubmed: 33375459
Hum Genet. 2016 Apr;135(4):425-439
pubmed: 26899160
BMJ Open. 2021 Jan 5;11(1):e039358
pubmed: 33402403
Nutr Neurosci. 2019 Sep;22(9):607-615
pubmed: 29298622
Mol Genet Genomics. 2012 Dec;287(11-12):837-44
pubmed: 23052833
Neurol Sci. 2014 Dec;35(12):1925-9
pubmed: 25008422