Relating MR relaxation times of
Journal
Osteoarthritis and cartilage open
ISSN: 2665-9131
Titre abrégé: Osteoarthr Cartil Open
Pays: England
ID NLM: 101767068
Informations de publication
Date de publication:
Jun 2020
Jun 2020
Historique:
entrez:
11
5
2021
pubmed:
12
5
2021
medline:
12
5
2021
Statut:
epublish
Résumé
Quantitative magnetic resonance imaging (MRI), e.g. relaxation parameter mapping, may be sensitive to structural and compositional tissue changes, and could potentially be used to non-invasively detect and monitor early meniscus degeneration related to knee osteoarthritis. To investigate MR relaxation times as potential biomarkers for meniscus degeneration through comparisons with histopathology. We measured MR relaxation parameters in the posterior horn of 40 menisci (medial and lateral) at a wide range of degenerative stages. T1, T2 and T2* were mapped using standard and ultrashort echo time sequences at 9.4 T and compared to gold standard histology using Pauli's histopathological scoring system, including assessment of surface integrity, collagen organization, cellularity and Safranin-O staining. All three relaxation times increased with total Pauli score (mean difference per score (95% CI) for T2*: 0.62 (0.37, 0.86), T2: 0.83 (0.53, 1.1) and T1: 24.7 (16.5, 32.8) ms/score). Clear associations were seen with scores of surface integrity (mean difference per score for T2*: 3.0 (1.8, 4.2), T2: 4.0 (2.5, 5.5) and T1: 116 (75.6, 156) ms/score) and collagen organization (mean difference between highest and lowest score for T2*: 5.3 (1.6, 8.9), T2: 6.1 (1.7, 11) and T1: 204 (75.9, 332) ms). The results were less clear for the remaining histopathological measures. MR relaxation times T1, T2 and T2* of
Sections du résumé
BACKGROUND
BACKGROUND
Quantitative magnetic resonance imaging (MRI), e.g. relaxation parameter mapping, may be sensitive to structural and compositional tissue changes, and could potentially be used to non-invasively detect and monitor early meniscus degeneration related to knee osteoarthritis.
OBJECTIVE
OBJECTIVE
To investigate MR relaxation times as potential biomarkers for meniscus degeneration through comparisons with histopathology.
METHODS
METHODS
We measured MR relaxation parameters in the posterior horn of 40 menisci (medial and lateral) at a wide range of degenerative stages. T1, T2 and T2* were mapped using standard and ultrashort echo time sequences at 9.4 T and compared to gold standard histology using Pauli's histopathological scoring system, including assessment of surface integrity, collagen organization, cellularity and Safranin-O staining.
RESULTS
RESULTS
All three relaxation times increased with total Pauli score (mean difference per score (95% CI) for T2*: 0.62 (0.37, 0.86), T2: 0.83 (0.53, 1.1) and T1: 24.7 (16.5, 32.8) ms/score). Clear associations were seen with scores of surface integrity (mean difference per score for T2*: 3.0 (1.8, 4.2), T2: 4.0 (2.5, 5.5) and T1: 116 (75.6, 156) ms/score) and collagen organization (mean difference between highest and lowest score for T2*: 5.3 (1.6, 8.9), T2: 6.1 (1.7, 11) and T1: 204 (75.9, 332) ms). The results were less clear for the remaining histopathological measures.
CONCLUSIONS
CONCLUSIONS
MR relaxation times T1, T2 and T2* of
Identifiants
pubmed: 33972933
doi: 10.1016/j.ocarto.2020.100061
pmc: PMC7610736
mid: EMS122080
pii:
doi:
Types de publication
Journal Article
Langues
eng
Subventions
Organisme : European Research Council
ID : 336267
Pays : International
Organisme : European Research Council
ID : 771121
Pays : International
Déclaration de conflit d'intérêts
Declaration of Competing Interest The authors have no conflicts of interest to declare.
Références
Arthritis Rheum. 2009 Mar;60(3):831-9
pubmed: 19248082
Osteoarthritis Cartilage. 1998 Jan;6(1):24-32
pubmed: 9616436
Quant Imaging Med Surg. 2016 Dec;6(6):731-743
pubmed: 28090449
Osteoarthritis Cartilage. 2011 Sep;19(9):1132-41
pubmed: 21683797
Magn Reson Med. 2014 Mar;71(3):1015-23
pubmed: 23606167
Knee Surg Sports Traumatol Arthrosc. 2008 Apr;16(4):353-9
pubmed: 18066525
Magn Reson Med. 2019 Feb;81(2):921-933
pubmed: 30269374
Osteoarthritis Cartilage. 2013 Jun;21(6):796-805
pubmed: 23499673
Skeletal Radiol. 2016 Dec;45(12):1649-1660
pubmed: 27639388
Ann Rheum Dis. 2011 Jan;70(1):74-9
pubmed: 20705634
NMR Biomed. 2013 Sep;26(9):1167-75
pubmed: 23505140
Top Magn Reson Imaging. 2010 Oct;21(5):275-89
pubmed: 22129641
J Magn Reson Imaging. 2012 Jan;35(1):147-55
pubmed: 21990043
Eur Radiol. 2019 Oct;29(10):5664-5672
pubmed: 30888480
Magn Reson Med. 2001 Sep;46(3):487-93
pubmed: 11550240
Osteoarthritis Cartilage. 2012 Jun;20(6):486-94
pubmed: 22306000
Magn Reson Med. 2004 Mar;51(3):503-9
pubmed: 15004791
Osteoarthritis Cartilage. 2019 Mar;27(3):476-483
pubmed: 30552967
J Magn Reson Imaging. 2015 Nov;42(5):1321-8
pubmed: 25847733
Radiology. 2005 Jan;234(1):162-70
pubmed: 15564387
Med Phys. 1984 Jul-Aug;11(4):425-48
pubmed: 6482839
Osteoarthritis Cartilage. 2019 Dec;27(12):1790-1799
pubmed: 31301431