Predictors of Lumbar Spine Degeneration and Low Back Pain in the Community: The Johnston County Osteoarthritis Project.
Journal
Arthritis care & research
ISSN: 2151-4658
Titre abrégé: Arthritis Care Res (Hoboken)
Pays: United States
ID NLM: 101518086
Informations de publication
Date de publication:
10 2022
10 2022
Historique:
revised:
23
04
2021
received:
20
08
2020
accepted:
04
05
2021
pubmed:
12
5
2021
medline:
1
10
2022
entrez:
11
5
2021
Statut:
ppublish
Résumé
To determine the incidence and worsening of lumbar spine structure and low back pain (LBP) and whether they are predicted by demographic characteristics or clinical characteristics or appendicular joint osteoarthritis (OA). Paired baseline (2003-2004) and follow-up (2006-2010) lumbar spine radiographs from the Johnston County Osteoarthritis Project were graded for osteophytes (OST), disc space narrowing (DSN), spondylolisthesis, and presence of facet joint OA (FOA). Spine OA was defined as at least mild OST and mild DSN at the same level for any level of the lumbar spine. LBP, comorbidities, and back injury were self-reported. Weibull models were used to estimate hazard ratios (HRs) and 95% confidence intervals (95% CIs) of spine phenotypes accounting for potential predictors including demographic characteristics, clinical characteristics, comorbidities, obesity, and appendicular OA. Obesity was a consistent and strong predictor of incidence of DSN (HR 1.80 [95% CI 1.09-2.98]), spine OA (HR 1.56 [95% CI 1.01-2.41]), FOA (HR 4.99 [95% CI 1.46-17.10]), spondylolisthesis (HR 1.87 [95% CI 1.02-3.43]), and LBP (HR 1.75 [95% CI 1.19-2.56]), and worsening of DSN (HR 1.51 [95% CI 1.09-2.09]) and LBP (HR 1.51 [95% CI 1.12-2.06]). Knee OA was a predictor of incident FOA (HR 4.18 [95% CI 1.44-12.2]). Spine OA (HR 1.80 [95% CI 1.24-2.63]) and OST (HR 1.85 [95% CI 1.02-3.36]) were predictors of incidence of LBP. Hip OA (HR 1.39 [95% CI 1.04-1.85]) and OST (HR 1.58 [95% CI 1.00-2.49]) were predictors of LBP worsening. Among the multiple predictors of spine phenotypes, obesity was a common predictor for both incidence and worsening of lumbar spine degeneration and LBP.
Identifiants
pubmed: 33973412
doi: 10.1002/acr.24643
pmc: PMC8578580
mid: NIHMS1704925
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, U.S. Gov't, P.H.S.
Langues
eng
Sous-ensembles de citation
IM
Pagination
1659-1666Subventions
Organisme : NIAMS NIH HHS
ID : R01 AR067743
Pays : United States
Organisme : NIAMS NIH HHS
ID : P60 AR049465
Pays : United States
Organisme : NCCDPHP CDC HHS
ID : U01 DP006266
Pays : United States
Organisme : NIAMS NIH HHS
ID : P60 AR030701
Pays : United States
Organisme : NIAMS NIH HHS
ID : R01 AR075399
Pays : United States
Organisme : NIAMS NIH HHS
ID : R01 AR071440
Pays : United States
Organisme : NIAMS NIH HHS
ID : L30 AR057661
Pays : United States
Organisme : NIA NIH HHS
ID : P30 AG028716
Pays : United States
Organisme : NIAMS NIH HHS
ID : R01 AR074800
Pays : United States
Organisme : NIAMS NIH HHS
ID : P30 AR072580
Pays : United States
Organisme : CDC HHS
ID : S043
Pays : United States
Organisme : CDC HHS
ID : S1734
Pays : United States
Organisme : CDC HHS
ID : S3486
Pays : United States
Informations de copyright
© 2021 American College of Rheumatology.
Références
Osteoarthritis Cartilage. 2007 Feb;15(2):120-7
pubmed: 17113325
N Engl J Med. 1994 Jul 14;331(2):69-73
pubmed: 8208267
Spine (Phila Pa 1976). 2009 Jan 1;34(1):E27-32
pubmed: 19127145
Arch Intern Med. 2009 Feb 9;169(3):251-8
pubmed: 19204216
Curr Rheumatol Rep. 2013 Feb;15(2):305
pubmed: 23307577
Ann Intern Med. 2007 Oct 2;147(7):478-91
pubmed: 17909209
Ann Rheum Dis. 1964 Mar;23:109-22
pubmed: 14130031
Spine (Phila Pa 1976). 1998 Sep 1;23(17):1868-73; discussion 1873-4
pubmed: 9762744
Spine (Phila Pa 1976). 2008 Nov 1;33(23):2560-5
pubmed: 18923337
Arthritis Care Res (Hoboken). 2020 Jul;72(7):974-981
pubmed: 31058435
Arthritis Rheum. 2011 Dec;63(12):3843-52
pubmed: 22020742
Spine (Phila Pa 1976). 1991 Sep;16(9):1015-21
pubmed: 1948392
J Rheumatol. 2004 Apr;31(4):753-8
pubmed: 15088303
Ann Rheum Dis. 2009 Sep;68(9):1401-6
pubmed: 18718988
J Rheumatol. 2007 Jan;34(1):172-80
pubmed: 17216685
BMJ. 2014 Jul 16;349:g4266
pubmed: 25030632
Osteoarthritis Cartilage. 2015 Mar;23(3):331-3
pubmed: 25454371
Spine (Phila Pa 1976). 2010 Mar 1;35(5):531-6
pubmed: 20147869
Rheumatol Int. 2017 Jun;37(6):983-991
pubmed: 28246962
Arthritis Care Res. 1995 Dec;8(4):242-50
pubmed: 8605262
J Arthroplasty. 2016 Jan;31(1):176-9
pubmed: 26276572
Ann Rheum Dis. 2007 Mar;66(3):426-7
pubmed: 17311902
Osteoarthritis Cartilage. 2017 Oct;25(10):1672-1679
pubmed: 28711584
Pain Med. 2015 May;16(5):886-97
pubmed: 25846648
Arthritis Rheum. 2003 Nov;48(11):3112-7
pubmed: 14613273
J Orthop Sci. 2012 May;17(3):213-8
pubmed: 22427017
Osteoarthritis Cartilage. 2017 Jun;25(6):809-816
pubmed: 28011100
Nat Rev Rheumatol. 2013 Apr;9(4):216-24
pubmed: 23147891
Arthritis Care Res (Hoboken). 2012 Oct;64(10):1536-44
pubmed: 22556059
Semin Arthritis Rheum. 2015 Apr;44(5):571-585
pubmed: 25684125
Arch Phys Med Rehabil. 2018 Jul;99(7):1273-1278
pubmed: 29111171
Eur Spine J. 2018 Nov;27(11):2791-2803
pubmed: 29971708
J R Coll Physicians Lond. 1984 Apr;18(2):132-41
pubmed: 6427451
J Rheumatol. 2010 Apr;37(4):842-50
pubmed: 20156951
Ann Rheum Dis. 1991 Mar;50(3):158-61
pubmed: 1826597
Contemp Clin Trials. 2015 Nov;45(Pt B):157-163
pubmed: 26493088
Ann Rheum Dis. 2007 Mar;66(3):330-3
pubmed: 17028115
Spine (Phila Pa 1976). 2007 Sep 1;32(19):2099-102
pubmed: 17762811
Osteoarthritis Cartilage. 2012 Jul;20(7):712-8
pubmed: 22484574
Annu Rev Public Health. 2002;23:23-44
pubmed: 11910053
Ann Phys Rehabil Med. 2022 Jan;65(1):101427
pubmed: 32798770