Magnetically Guided Nanoworms for Precise Delivery to Enhance In Situ Production of Nitric Oxide to Combat Focal Bacterial Infection In Vivo.
Animals
Anti-Bacterial Agents
/ therapeutic use
Bacterial Infections
/ drug therapy
Cell Line, Tumor
Drug Delivery Systems
Drug Screening Assays, Antitumor
Humans
Magnetics
Male
Mice
Mice, Inbred BALB C
Microbial Sensitivity Tests
Nanostructures
Nitric Oxide
/ biosynthesis
Xenograft Model Antitumor Assays
magnetic guidance
nanoworms
nitric oxide
photothermal therapy
targeted delivery
Journal
ACS applied materials & interfaces
ISSN: 1944-8252
Titre abrégé: ACS Appl Mater Interfaces
Pays: United States
ID NLM: 101504991
Informations de publication
Date de publication:
19 May 2021
19 May 2021
Historique:
pubmed:
12
5
2021
medline:
28
8
2021
entrez:
11
5
2021
Statut:
ppublish
Résumé
Overexploitation of antibiotics increases the emergence of multidrug-resistant agents (MDRAs), which may potentially cause a global crisis with severe health consequences. Hence, there is great demand for next-generation antibacterial platforms based on antibiotic-free strategies or targeted therapies to mitigate the emergence of MDRAs. Herein, an all-in-one hollow nanoworm (A-Fe/AuAg@PDA) is developed with a core comprising citrate-capped Au-Ag nanoparticles (Cit-AuAg NPs) loaded with Fe
Identifiants
pubmed: 33973760
doi: 10.1021/acsami.1c04330
doi:
Substances chimiques
Anti-Bacterial Agents
0
Nitric Oxide
31C4KY9ESH
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM