Deazapurine Nucleoside Analogues for the Treatment of
Trichomonas vaginalis
high-throughput screening
mouse model
nucleoside analog
tubercidin
Journal
ACS infectious diseases
ISSN: 2373-8227
Titre abrégé: ACS Infect Dis
Pays: United States
ID NLM: 101654580
Informations de publication
Date de publication:
11 06 2021
11 06 2021
Historique:
pubmed:
12
5
2021
medline:
24
6
2021
entrez:
11
5
2021
Statut:
ppublish
Résumé
Trichomoniasis is the most common nonviral sexually transmitted disease in humans, but treatment options are limited. Here, we report a resorufin-based drug sensitivity assay for high-throughput microplate-based screening under hypoxic conditions. A 5203-compound enamine kinase library and several specialized compound series were tested for the inhibition of
Identifiants
pubmed: 33974405
doi: 10.1021/acsinfecdis.1c00075
pmc: PMC9586919
mid: NIHMS1825207
doi:
Substances chimiques
Nucleosides
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1752-1764Subventions
Organisme : NIDDK NIH HHS
ID : P30 DK120515
Pays : United States
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