Effect of zinc deficiency on chronic kidney disease progression and effect modification by hypoalbuminemia.
Aged
Aged, 80 and over
Disease Progression
Female
Glomerular Filtration Rate
Humans
Hypoalbuminemia
/ blood
Japan
/ epidemiology
Kaplan-Meier Estimate
Kidney Failure, Chronic
/ blood
Male
Middle Aged
Propensity Score
Renal Insufficiency, Chronic
/ blood
Retrospective Studies
Risk Factors
Zinc
/ deficiency
Journal
PloS one
ISSN: 1932-6203
Titre abrégé: PLoS One
Pays: United States
ID NLM: 101285081
Informations de publication
Date de publication:
2021
2021
Historique:
received:
02
02
2021
accepted:
27
04
2021
entrez:
11
5
2021
pubmed:
12
5
2021
medline:
26
10
2021
Statut:
epublish
Résumé
Serum zinc (Zn) levels tend to be low in chronic kidney disease (CKD) patients. This cohort study was conducted to investigate the relationship between zinc deficiency and CKD progression. Patients were classified into two groups based on Zn levels < 60 μg/dl (low-Zn group, n = 160) and ≥ 60 μg/dl (high-Zn group, n = 152). The primary outcome was defined as end-stage kidney disease (ESKD) or death and was examined over a 1-year observation period. Overall, the mean Zn level was 59.6 μg/dl and the median eGFR was 20.3 ml/min/1.73 m2. The incidence of the primary outcome was higher in the low-Zn group (p<0.001). Various Cox proportional hazards models adjusted for baseline characteristics showed higher risks of the primary outcome in the low-Zn group than in the high-Zn group. Competing risks analysis showed that low Zn levels were associated with ESKD but not with death. Moreover, in propensity score-matched analysis, the low-Zn group showed a higher risk of the primary outcome [adjusted hazard ratio 1.81 (95% confidence interval 1.02, 3.24)]. Furthermore, an interaction was observed between Zn and serum albumin levels (interaction p = 0.026). The results of this study indicate that zinc deficiency is a risk factor for CKD progression.
Identifiants
pubmed: 33974681
doi: 10.1371/journal.pone.0251554
pii: PONE-D-21-03589
pmc: PMC8112700
doi:
Substances chimiques
Zinc
J41CSQ7QDS
Types de publication
Comparative Study
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
e0251554Déclaration de conflit d'intérêts
The authors have declared that no competing interests exist.
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