Ubiquitin ligases in cancer: Functions and clinical potentials.
Journal
Cell chemical biology
ISSN: 2451-9448
Titre abrégé: Cell Chem Biol
Pays: United States
ID NLM: 101676030
Informations de publication
Date de publication:
15 07 2021
15 07 2021
Historique:
received:
26
01
2021
revised:
23
03
2021
accepted:
08
04
2021
pubmed:
12
5
2021
medline:
17
11
2021
entrez:
11
5
2021
Statut:
ppublish
Résumé
Ubiquitylation, a highly regulated post-translational modification, controls many cellular pathways that are critical to cell homeostasis. Ubiquitin ligases recruit substrates and promote ubiquitin transfer onto targets, inducing proteasomal degradation or non-degradative signaling. Accumulating evidence highlights the critical role of dysregulated ubiquitin ligases in processes associated with the initiation and progression of cancer. Depending on the substrate specificity and biological context, a ubiquitin ligase can act either as a tumor promoter or as a tumor suppressor. In this review, we focus on the regulatory roles of ubiquitin ligases and how perturbations of their functions contribute to cancer pathogenesis. We also briefly discuss current strategies for targeting or exploiting ubiquitin ligases for cancer therapy.
Identifiants
pubmed: 33974914
pii: S2451-9456(21)00201-4
doi: 10.1016/j.chembiol.2021.04.008
pmc: PMC8286310
mid: NIHMS1693436
pii:
doi:
Substances chimiques
Ubiquitin-Protein Ligases
EC 2.3.2.27
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
918-933Subventions
Organisme : NCI NIH HHS
ID : R01 CA076584
Pays : United States
Organisme : NIGMS NIH HHS
ID : R35 GM136250
Pays : United States
Organisme : NCI NIH HHS
ID : T32 CA009161
Pays : United States
Informations de copyright
Copyright © 2021 Elsevier Ltd. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of interests M.P. is a consultant for and has financial interests in Coho Therapeutics, CullGen, Kymera Therapeutics, and SEED Therapeutics. M.P. is a cofounder of Coho Therapeutics, is on the SAB of CullGen and Kymera Therapeutics, and is a consultant for Santi Therapeutics. S.D. declares no competing interests.
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