Long non-coding RNA LINC00649 regulates YES-associated protein 1 (YAP1)/Hippo pathway to accelerate gastric cancer (GC) progression via sequestering miR-16-5p.
Adaptor Proteins, Signal Transducing
/ metabolism
Animals
Base Sequence
Cell Line, Tumor
Disease Progression
Female
Gene Expression Regulation, Neoplastic
Gene Knockdown Techniques
Hippo Signaling Pathway
Humans
Mice, Inbred BALB C
Mice, Nude
MicroRNAs
/ genetics
Phenotype
Protein Serine-Threonine Kinases
/ metabolism
RNA, Long Noncoding
Signal Transduction
Stomach Neoplasms
/ genetics
Transcription Factors
/ metabolism
YAP-Signaling Proteins
Gastric cancer
LINC00649
YES-associated protein 1
cancer biology
miR-16-5p
Journal
Bioengineered
ISSN: 2165-5987
Titre abrégé: Bioengineered
Pays: United States
ID NLM: 101581063
Informations de publication
Date de publication:
12 2021
12 2021
Historique:
entrez:
12
5
2021
pubmed:
13
5
2021
medline:
11
11
2021
Statut:
ppublish
Résumé
Although long non-coding RNA (LncRNA) LINC00649 is reported to be closely associated with acute myeloid leukemia (AML), prostate cancer and colorectal cancer, its role in regulating other types of cancer, such as gastric cancer (GC), has not been studied. This study analyzed the expression status of LINC00649 in GC tissues and cells by performing Real-Time qPCR analysis, and we found that LINC00649 tended to be enriched in cancerous tissues and cells but not in their normal counterparts, which were supported by the data from TCGA dataset. Next, by performing the gain- and loss-of-function experiments, we expectedly found that LINC00649 acted as an oncogene to accelerate GC cell proliferation, migration and epithelial-mesenchymal transition (EMT)
Identifiants
pubmed: 33975517
doi: 10.1080/21655979.2021.1924554
pmc: PMC8806528
doi:
Substances chimiques
Adaptor Proteins, Signal Transducing
0
MIRN16 microRNA, human
0
MicroRNAs
0
RNA, Long Noncoding
0
Transcription Factors
0
YAP-Signaling Proteins
0
YAP1 protein, human
0
Protein Serine-Threonine Kinases
EC 2.7.11.1
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
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