Early detection of gastric cancer beyond endoscopy - new methods.
Biomarkers
Gastric cancer
Methods
Journal
Best practice & research. Clinical gastroenterology
ISSN: 1532-1916
Titre abrégé: Best Pract Res Clin Gastroenterol
Pays: Netherlands
ID NLM: 101120605
Informations de publication
Date de publication:
Historique:
received:
27
11
2020
accepted:
08
02
2021
entrez:
12
5
2021
pubmed:
13
5
2021
medline:
22
5
2021
Statut:
ppublish
Résumé
Early detection of gastric cancer is remaining a challenge. This review summarizes current knowledge on non-invasive methods that could be used for the purpose. The role of traditional cancer markers such as CEA, CA 72-4, CA 19-9, CA 15-3, and CA 12-5 lies mainly in therapy monitoring than early detection. Most extensive studied biomarkers (pepsinogens, ABC method) are aiming at the detection of precancerous lesions with modest sensitivity for cancer. Tests based on the detection of cancer-specific methylation patterns (PanSeer), circulating proteins and mutations in circulating tumour DNA (CancerSEEK), as well as miRNA panels have demonstrated promising results bringing those closer to practice. More extensive research is required before tests based on the detection of circulating tumour cells, extracellular vesicles and cell-free RNA could reach the practice. Detection of volatile organic compounds in the human breath is a promising development; sensor technologies for this purpose could be very attractive in screening settings.
Identifiants
pubmed: 33975677
pii: S1521-6918(21)00007-X
doi: 10.1016/j.bpg.2021.101731
pii:
doi:
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
101731Informations de copyright
Copyright © 2021 Elsevier Ltd. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of competing interest None.