The MNK1/2-eIF4E Axis Supports Immune Suppression and Metastasis in Postpartum Breast Cancer.
Journal
Cancer research
ISSN: 1538-7445
Titre abrégé: Cancer Res
Pays: United States
ID NLM: 2984705R
Informations de publication
Date de publication:
15 07 2021
15 07 2021
Historique:
received:
15
09
2020
revised:
08
04
2021
accepted:
10
05
2021
pubmed:
13
5
2021
medline:
28
1
2022
entrez:
12
5
2021
Statut:
ppublish
Résumé
Breast cancer diagnosed within 10 years following childbirth is defined as postpartum breast cancer (PPBC) and is highly metastatic. Interactions between immune cells and other stromal cells within the involuting mammary gland are fundamental in facilitating an aggressive tumor phenotype. The MNK1/2-eIF4E axis promotes translation of prometastatic mRNAs in tumor cells, but its role in modulating the function of nontumor cells in the PPBC microenvironment has not been explored. Here, we used a combination of
Identifiants
pubmed: 33975880
pii: 0008-5472.CAN-20-3143
doi: 10.1158/0008-5472.CAN-20-3143
doi:
Substances chimiques
Eukaryotic Initiation Factor-4E
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
3876-3889Subventions
Organisme : CIHR
ID : MOP-142281
Pays : Canada
Organisme : CIHR
ID : PJT-156269
Pays : Canada
Organisme : CIHR
ID : PJT-162260
Pays : Canada
Informations de copyright
©2021 American Association for Cancer Research.
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