IDH2 mutations in patients with normal karyotype AML predict favorable responses to daunorubicin, cytarabine and cladribine regimen.

Adolescent Adult Aged Antineoplastic Agents / therapeutic use Antineoplastic Combined Chemotherapy Protocols Cladribine / therapeutic use Cytarabine / therapeutic use Daunorubicin / therapeutic use Humans Isocitrate Dehydrogenase / genetics Leukemia, Myeloid, Acute / drug therapy Middle Aged Pharmacogenomic Variants Poland / epidemiology Randomized Controlled Trials as Topic Retrospective Studies Young Adult

Journal

Scientific reports

ISSN: 2045-2322

Titre abrégé: Sci Rep

Pays: England

ID NLM: 101563288

Informations de publication

Date de publication:
11 05 2021

Historique:

received: 02 03 2020

accepted: 05 03 2021

entrez: 12 5 2021

pubmed: 13 5 2021

medline: 5 11 2021

Statut: epublish

Résumé

Mutations in isocitrate dehydrogenase 1 and 2 (IDH1/2) genes occur in about 20% patients with acute myeloid leukemia (AML), leading to DNA hypermethylation and epigenetic deregulation. We assessed the prognostic significance of IDH1/2 mutations (IDH1/2

Identifiants

DOI: 10.1038/s41598-021-88120-y PMID: 33976256 PMC: PMC8113255

pubmed: 33976256

doi: 10.1038/s41598-021-88120-y

pii: 10.1038/s41598-021-88120-y

pmc: PMC8113255

doi:

Substances chimiques

Antineoplastic Agents 0

Cytarabine 04079A1RDZ

Cladribine 47M74X9YT5

IDH2 protein, human EC 1.1.1.41

Isocitrate Dehydrogenase EC 1.1.1.41

Daunorubicin ZS7284E0ZP

Types de publication

Journal Article Multicenter Study Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

Pagination

10017

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