High resolution structural and functional MRI of the hippocampus in young adults with Down syndrome.
Down syndrome
MRI
functional connectivity
hippocampus
spatial memory
Journal
Brain communications
ISSN: 2632-1297
Titre abrégé: Brain Commun
Pays: England
ID NLM: 101755125
Informations de publication
Date de publication:
2021
2021
Historique:
received:
29
07
2020
revised:
19
02
2021
accepted:
22
03
2021
entrez:
12
5
2021
pubmed:
13
5
2021
medline:
13
5
2021
Statut:
epublish
Résumé
Down syndrome is the phenotypic consequence of trisomy 21, with clinical presentation including both neurodevelopmental and neurodegenerative components. Although the intellectual disability typically displayed by individuals with Down syndrome is generally global, it also involves disproportionate deficits in hippocampally-mediated cognitive processes. Hippocampal dysfunction may also relate to Alzheimer's disease-type pathology, which can appear in as early as the first decade of life and becomes universal by age 40. Using 7-tesla MRI of the brain, we present an assessment of the structure and function of the hippocampus in 34 individuals with Down syndrome (mean age 24.5 years ± 6.5) and 27 age- and sex-matched typically developing healthy controls. In addition to increased whole-brain mean cortical thickness and lateral ventricle volumes (
Identifiants
pubmed: 33977271
doi: 10.1093/braincomms/fcab088
pii: fcab088
pmc: PMC8100000
doi:
Types de publication
Journal Article
Langues
eng
Pagination
fcab088Subventions
Organisme : NIA NIH HHS
ID : P30 AG062428
Pays : United States
Informations de copyright
© The Author(s) (2021). Published by Oxford University Press on behalf of the Guarantors of Brain.
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