The probable destructive mechanisms behind COVID-19 on male reproduction system and fertility.
COVID-19
Male reproduction
SARS-CoV-2
Sperm
Testis
Journal
Journal of assisted reproduction and genetics
ISSN: 1573-7330
Titre abrégé: J Assist Reprod Genet
Pays: Netherlands
ID NLM: 9206495
Informations de publication
Date de publication:
Jul 2021
Jul 2021
Historique:
received:
16
11
2020
accepted:
28
01
2021
pubmed:
13
5
2021
medline:
10
8
2021
entrez:
12
5
2021
Statut:
ppublish
Résumé
The present study aims to summarize the current understanding of probable mechanisms and claims of adverse effects of SARS-CoV-2 on male fertility potential. Our search was including original articles, reviews, guidelines, letters to the editor, comments on guidelines, and editorials, regarding the male reproductive system. We used the words SARS-CoV-2, coronavirus, severe acute respiratory syndrome coronavirus 2, "2019 ncov," testis, sperm, male factor infertility, fertility treatment, semen, assisted reproductive technology (ART), sexual transmission, and ACE2. Data showed coronavirus affects men more than women because of more expression of 2019 nCoV receptors (ACE2 and TMPRSS2) in testicular cells. Also, "Bioinformatics Analysis" suggests that sperm production may be damaged, since "Pseudo Time Analysis" has shown disruption in spermatogenesis. "Gene Ontology" (GO) showed an increase in viral reproduction and a decrease in sperm production-related terms. Recently, SARS-COV-2 mRNA and protein were detected in the semen of patients that had recovered from SARS-CoV-2 infection. Therefore, the probable disruption of blood-testis barrier (BTB) in febrile diseases is suspected in the acute phase of the disease enabling viral entry into the testes. Not only is spermatogenesis disturbed, but also disturbs gonadotropin, androgens, and testosterone secretion during SARS-CoV-2 infection. No sexual transmission has been reported yet; however, detection of the virus in semen still makes the sexual transmission an open question. There is a concern that male fertility may be disturbed after the SARS-CoV-2 infection. Therefore, follow-up of the reproductive functions and male fertility may be necessary in recovered cases, especially in aged men.
Identifiants
pubmed: 33977466
doi: 10.1007/s10815-021-02097-1
pii: 10.1007/s10815-021-02097-1
pmc: PMC8112744
doi:
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
1691-1708Informations de copyright
© 2021. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.
Références
Lancet. 2020 Mar 14;395(10227):846-848
pubmed: 32151325
Viruses. 2020 Jan 24;12(2):
pubmed: 31991541
Med Mal Infect. 2020 Jun;50(4):332-334
pubmed: 32243911
Reprod Sci. 2019 Oct;26(10):1326
pubmed: 33630280
J Endocrinol Invest. 2020 Dec;43(12):1819-1822
pubmed: 32329026
Nature. 2020 Mar;579(7798):270-273
pubmed: 32015507
Am J Clin Pathol. 2020 May 5;153(6):725-733
pubmed: 32275742
Reprod Biomed Online. 2020 Aug;41(2):157-159
pubmed: 32466995
Int J Infect Dis. 2020 Jun;95:391-398
pubmed: 32339715
Nat Rev Urol. 2020 Jun;17(6):314-315
pubmed: 32313110
Lancet. 2020 Feb 22;395(10224):565-574
pubmed: 32007145
J Diabetes Investig. 2015 Mar;6(2):112-23
pubmed: 25802717
J Virol. 2014 Jan;88(2):1293-307
pubmed: 24227843
Endocrine. 2017 Dec;58(3):397-407
pubmed: 28429281
Andrologia. 2020 Oct;52(9):e13712
pubmed: 32578263
N Engl J Med. 2020 Mar 26;382(13):1199-1207
pubmed: 31995857
Andrologia. 2018 Dec;50(11):e13140
pubmed: 30569651
Andrologia. 2021 Feb;53(1):e13883
pubmed: 33108833
PLoS One. 2015 May 26;10(5):e0127515
pubmed: 26010093
Ann N Y Acad Sci. 1951 Mar;53(3):708-28
pubmed: 14819896
Sci Rep. 2019 Nov 7;9(1):16262
pubmed: 31700161
Cell Res. 2017 Jan;27(1):119-129
pubmed: 28008928
Andrology. 2021 Jan;9(1):73-79
pubmed: 32869939
Aging Clin Exp Res. 2020 Oct;32(10):2141-2158
pubmed: 32876941
Emerg Infect Dis. 2017 Nov;23(11):1922-1924
pubmed: 29048276
J Virol. 2019 Oct 15;93(21):
pubmed: 31391268
Reprod Biomed Online. 2020 Jun;40(6):905
pubmed: 32334942
Cells. 2020 Apr 09;9(4):
pubmed: 32283711
Am J Respir Crit Care Med. 2020 Sep 1;202(5):756-759
pubmed: 32663409
N Engl J Med. 2020 Apr 30;382(18):1708-1720
pubmed: 32109013
Endocrinology. 2004 Oct;145(10):4703-11
pubmed: 15231706
Andrology. 2021 Jan;9(1):48-52
pubmed: 32649023
Fertil Steril. 2020 Jun;113(6):1140-1149
pubmed: 32482250
Eur Urol Focus. 2020 Sep 15;6(5):1124-1129
pubmed: 32563676
Asian J Androl. 2016 May-Jun;18(3):357-63
pubmed: 27098657
Clin Gastroenterol Hepatol. 2020 Aug;18(9):2128-2130.e2
pubmed: 32334082
J Cosmet Dermatol. 2020 Jul;19(7):1545-1547
pubmed: 32301221
J Reprod Immunol. 2020 Nov;142:103213
pubmed: 33080435
Annu Rev Virol. 2016 Sep 29;3(1):237-261
pubmed: 27578435
Fertil Steril. 2020 Jun;113(6):1135-1139
pubmed: 32482249
Cancer Discov. 2014 Nov;4(11):1310-25
pubmed: 25122198
J Exp Med. 2005 Aug 1;202(3):415-24
pubmed: 16043521
J Clin Endocrinol Metab. 2020 May 1;105(5):
pubmed: 32232480
Semin Cell Dev Biol. 2014 Jun;30:2-13
pubmed: 24598768
Andrologia. 1998 Aug-Sep;30(4-5):207-15
pubmed: 9739417
Urology. 2020 Aug;142:42
pubmed: 32343996
FASEB J. 2006 Nov;20(13):2321-8
pubmed: 17077309
Fertil Steril. 2020 Aug;114(2):233-238
pubmed: 32650948
Lancet Infect Dis. 2020 Jun;20(6):656-657
pubmed: 32199493
Andrologia. 2021 Mar;53(2):e13912
pubmed: 33244788
J Endocrinol Invest. 2021 May;44(5):1091-1096
pubmed: 33040303
Lancet. 2020 Mar 7;395(10226):809-815
pubmed: 32151335
Fertil Steril. 2020 Jul;114(1):33-43
pubmed: 32622411
Reprod Sci. 2021 Jan;28(1):23-26
pubmed: 32651900
J Investig Dermatol Symp Proc. 2005 Dec;10(3):184-9
pubmed: 16382660
Reproduction. 2020 Mar;159(3):241-249
pubmed: 31869308
Proc Natl Acad Sci U S A. 2005 Aug 16;102(33):11876-81
pubmed: 16081529
Emerg Infect Dis. 2018 Mar;24(3):602-603
pubmed: 29460761
Andrologia. 2013 Dec;45(6):379-85
pubmed: 23013062
J Virol. 2011 May;85(9):4122-34
pubmed: 21325420
Cancer Cytopathol. 2020 May;128(5):317-320
pubmed: 32259373
Pharmacol Rev. 2012 Jan;64(1):16-64
pubmed: 22039149
Reprod Biomed Online. 2020 Nov;41(5):903-906
pubmed: 32826162
Br J Dermatol. 2003 Dec;149(6):1207-13
pubmed: 14674898
Reprod Biomed Online. 2016 Feb;32(2):162-9
pubmed: 26706459
Biosci Rep. 2017 Jun 27;37(3):
pubmed: 28515223
Can Urol Assoc J. 2020 May;14(5):E161-E166
pubmed: 32369009
Respir Med. 2020 Jul;168:105980
pubmed: 32364959
Infect Drug Resist. 2020 Nov 04;13:3977-3990
pubmed: 33177848
Andrology. 2021 Jan;9(1):10-18
pubmed: 32357288
J Clin Pathol. 2020 May;73(5):239-242
pubmed: 32198191
Fertil Steril. 2020 Jun;113(6):1131-1132
pubmed: 32482248
Theriogenology. 2013 Nov;80(8):923-32
pubmed: 23987985
J Cell Mol Med. 2020 Aug;24(16):9472-9477
pubmed: 32594644
Lancet Respir Med. 2020 Apr;8(4):e20
pubmed: 32171067
Front Med (Lausanne). 2021 Jan 13;7:563893
pubmed: 33521006
Reproduction. 2015 Apr;149(4):R159-67
pubmed: 25504872
Nat Rev Urol. 2019 Apr;16(4):211-230
pubmed: 30696994
Eur J Contracept Reprod Health Care. 2020 Oct;25(5):405-406
pubmed: 32643968
Chest. 2020 May;157(5):1175-1187
pubmed: 31730835
Am J Obstet Gynecol. 2017 Jul;217(1):4-10
pubmed: 28209492
Nat Rev Microbiol. 2013 Dec;11(12):836-48
pubmed: 24217413
J Endocr Soc. 2020 Jul 02;4(8):bvaa082
pubmed: 32728654
Biol Sex Differ. 2010 Nov 05;1(1):6
pubmed: 21208466
Molecules. 2020 Oct 29;25(21):
pubmed: 33137894
J Travel Med. 2020 Mar 13;27(2):
pubmed: 32052846
Zhonghua Liu Xing Bing Xue Za Zhi. 2020 Feb 10;41(2):145-151
pubmed: 32064853
J Androl. 2011 Nov-Dec;32(6):625-40
pubmed: 21764900
Vet Comp Oncol. 2019 Sep;17(3):317-328
pubmed: 30854786
J Reprod Immunol. 2003 Feb;58(1):1-26
pubmed: 12609522
Urology. 2020 Oct;144:1-3
pubmed: 32653566
Am J Cardiol. 1998 Nov 19;82(10A):5S-7S
pubmed: 9860346
Biol Reprod. 2018 Jul 1;99(1):101-111
pubmed: 29566165
Lab Invest. 2020 Nov;100(11):1485-1489
pubmed: 32647285
Andrology. 2021 Jan;9(1):99-106
pubmed: 33150723
Sci China Life Sci. 2020 Jul;63(7):1006-1015
pubmed: 32361911
J Virol. 2012 Sep;86(18):10112-22
pubmed: 22787216
Crit Care. 2017 Dec 11;21(1):300
pubmed: 29228951
EClinicalMedicine. 2020 Nov;28:100604
pubmed: 33134901
J Clin Endocrinol Metab. 2011 Oct;96(10):3007-19
pubmed: 21816776
Fertil Steril. 2005 Oct;84(4):1001-10
pubmed: 16213856
Cancer. 2001 Dec 1;92(11):2778-85
pubmed: 11753951
Am J Pathol. 2007 Apr;170(4):1136-47
pubmed: 17392154
Cell Mol Immunol. 2014 Sep;11(5):428-37
pubmed: 24954222
Front Immunol. 2012 Jun 11;3:152
pubmed: 22701457
Biol Reprod. 2020 Jun 23;103(1):4-6
pubmed: 32297920
J Med Virol. 2020 Sep;92(9):1676-1680
pubmed: 32330305
Endocrinology. 2004 Feb;145(2):692-8
pubmed: 14576178
Syst Biol Reprod Med. 2019 Aug;65(4):265-272
pubmed: 31014114
Front Med. 2020 Apr;14(2):185-192
pubmed: 32170560
Andrology. 2020 Sep;8(5):970-987
pubmed: 32026626
Arch Pathol Lab Med. 2020 Jul 1;144(7):799-805
pubmed: 32180426
J Assist Reprod Genet. 2016 Sep;33(9):1255-6
pubmed: 27241530
PLoS Pathog. 2018 Aug 13;14(8):e1007236
pubmed: 30102747
Prostate. 2013 Jun;73(8):789-800
pubmed: 23620238
Theriogenology. 2013 Dec;80(9):1052-60
pubmed: 24055398
Andrology. 2021 Jan;9(1):88-98
pubmed: 32436355
JAMA Netw Open. 2020 May 1;3(5):e208292
pubmed: 32379329
Microorganisms. 2020 Sep 28;8(10):
pubmed: 32998451
J Virol. 2018 Sep 12;92(19):
pubmed: 30021901
Lancet. 2020 Mar 28;395(10229):1033-1034
pubmed: 32192578
Med Hypotheses. 2020 Oct;143:110083
pubmed: 32679425
J Infect. 2020 Aug;81(2):e102-e103
pubmed: 32425274
Endocrinology. 2019 May 1;160(5):1323-1332
pubmed: 30901026
Hum Pathol. 2007 Jan;38(1):95-102
pubmed: 16996569
JAMA. 2020 May 12;323(18):1843-1844
pubmed: 32159775
Endocr Rev. 2015 Oct;36(5):564-91
pubmed: 26357922
Cell. 2020 Apr 16;181(2):271-280.e8
pubmed: 32142651
Dermatol Ther. 2020 Jul;33(4):e13365
pubmed: 32237190
Biol Reprod. 2006 Feb;74(2):410-6
pubmed: 16237152
Reproduction. 2010 May;139(5):893-903
pubmed: 20154176
Lancet Respir Med. 2020 May;8(5):475-481
pubmed: 32105632
Andrology. 2021 Jan;9(1):42-47
pubmed: 32598557
Oncogene. 2007 Mar 22;26(13):1875-84
pubmed: 16983333
Hum Pathol. 2005 Mar;36(3):303-9
pubmed: 15791576
Front Public Health. 2020 Apr 29;8:152
pubmed: 32411652
Boll Chim Farm. 1997 Jan;136(1):39-43
pubmed: 9080720
Am J Physiol Endocrinol Metab. 2020 Jun 1;318(6):E878-E880
pubmed: 32421367
J Med Virol. 2020 Oct;92(10):2050-2054
pubmed: 32383183
Reprod Biomed Online. 2020 Jun;40(6):763-764
pubmed: 32362571
Reprod Fertil Dev. 2014;26(4):533-9
pubmed: 23683542
Am J Pathol. 2010 Jun;176(6):2986-96
pubmed: 20382709
Rev Urol. 2004;6 Suppl 6:S3-8
pubmed: 16985909