A rare case of childhood mucous membrane pemphigoid involving the oral and genital mucosa.
immunobullous disease
mucous membrane disorders
Journal
Pediatric dermatology
ISSN: 1525-1470
Titre abrégé: Pediatr Dermatol
Pays: United States
ID NLM: 8406799
Informations de publication
Date de publication:
Jul 2021
Jul 2021
Historique:
pubmed:
13
5
2021
medline:
1
9
2021
entrez:
12
5
2021
Statut:
ppublish
Résumé
Mucous membrane pemphigoid (MMP) is a rare chronic immunobullous disease that involves the mucous membranes and may result in significant scarring and complications if diagnosis is delayed. MMP typically occurs in elderly patients, with very few cases reported in children. Here, we present a 12-year-old female patient with childhood-onset oral and genital MMP, clinically suspected to be lichen sclerosus, but eventually diagnosed as MMP after multiple supportive biopsies and confirmatory direct immunofluorescence. Although treatment was challenging, the combined use of systemic corticosteroids, dapsone, and mycophenolate mofetil was ultimately successful in achieving disease control.
Substances chimiques
Dapsone
8W5C518302
Types de publication
Case Reports
Langues
eng
Sous-ensembles de citation
IM
Pagination
904-907Informations de copyright
© 2021 Wiley Periodicals LLC.
Références
Lavallee A, Bourret-Massicotte D, Laughrea PA. Childhood mucous membrane pemphigoid: a case with exclusively ocular involvement. Cornea. 2013;32(10):1399-1401.
Kahn E, Spence Shishido A, Yancey KB, Lawley LP. Anti-laminin-332 mucous membrane pemphigoid in a 9-year old girl. Pediatr Dermatol. 2014;31(3):e76-79.
Kharfi M, Khaled A, Anane R, Fazaa B, Kamoun MR. Early onset childhood cicatricial pemphigoid: a case report and review of the literature. Pediatr Dermatol. 2010;27(2):119-124.
Mostafa M, Hassib N, Nemat A. Oral mucous membrane pemphigoid in a 6-year-old boy: diagnosis, treatment and 4 years follow-up. Int J Paediatr Dent. 2010;20(1):76-79.
Flores-Climente V, Rozas-Muñoz E, Martínez-Grau A, Aucouturier F, Luna S, Baselga E. Childhood ocular mucous membrane pemphigoid successfully treated with rituximab. Pediatr Dermatol. 2019;36(6):984-985.
Silva B, Tomeh J, Lima K, Silva L, Sant'Ana S, Yamamoto-Silva F. Systemic corticosteroid in the treatment of a 9-year-old boy with oral mucous membrane pemphigoid: a case report. Rev Odontol Bras Central. 2017;26:41-44.
Pattnaik M, Panda M, Dash M, Raj C. A rare case of childhood mucous membrane pemphigoid involving both skin and mucosa. Indian J Pediatr Dermatol. 2019;20(2):160-162.
Cheng YS, Rees TD, Wright JM, Plemons JM. Childhood oral pemphigoid: a case report and review of the literature. J Oral Pathol Med. 2001;30(6):372-377.
Farrell AM, Kirtschig G, Dalziel KL, et al. Childhood vulval pemphigoid: a clinical and immunopathological study of five patients. Br J Dermatol. 1999;140(2):308-312.
Hoque SR, Patel M, Farrell AM. Childhood cicatricial pemphigoid confined to the vulva. Clin Exp Dermatol. 2006;31(1):63-64.
Marren P, Walkden V, Mallon E, Wojnarowska F. Vulval cicatricial pemphigoid may mimic lichen sclerosus. Br J Dermatol. 1996;134(3):522-524.
Waisbourd-Zinman O, Ben-Amitai D, Cohen AD, et al. Bullous pemphigoid in infancy: clinical and epidemiologic characteristics. J Am Acad Dermatol. 2008;58(1):41-48.
Pandhi D, Singal A, Bhattacharya SN. Lichen planus in childhood: a series of 316 patients. Pediatr Dermatol. 2014;31(1):59-67.
Rogers M, Painter D. Cicatricial pemphigoid in a four-year-old child: a case report. Australas J Dermatol. 1981;22(1):21-23.
Fleming TE, Korman NJ. Cicatricial pemphigoid. J Am Acad Dermatol. 2000;43(4):571-591.
Carey B, Joshi S, Abdelghani A, Mee J, Andiappan M, Setterfield J. The optimal oral biopsy site for diagnosis of mucous membrane pemphigoid and pemphigus vulgaris. Br J Dermatol. 2020;182(3):747-753.
Shimanovich I, Nitz JM, Zillikens D. Multiple and repeated sampling increases the sensitivity of direct immunofluorescence testing for the diagnosis of mucous membrane pemphigoid. J Am Acad Dermatol. 2017;77(4):700-705.e703.
Moy W, Kumar V, Friedman RP, Schaeffer ML, Beutner E, Helm F. Cicatricial pemphigoid. A case of onset at age 5. J Periodontol. 1986;57(1):39-43.
Mimouni D, Anhalt GJ, Lazarova Z, et al. Paraneoplastic pemphigus in children and adolescents. Br J Dermatol. 2002;147(4):725-732.
La Placa M, Balestri R, Tartari F, et al. Mucous membrane pemphigoid-associated malignancies: case series and a brief overview of the literature. Dermatol Pract Concept. 2019;9(2):119-125.
Hübner F, König IR, Holtsche MM, Zillikens D, Linder R, Schmidt E. Prevalence and age distribution of pemphigus and pemphigoid diseases among paediatric patients in Germany. J Eur Acad Dermatol Venereol. 2020;34(11):2800-2805.
Lara-Corrales I, Pope E. Autoimmune blistering diseases in children. Semin Cutan Med Surg. 2010;29(2):85-91.
Diercks GF, Pas HH, Jonkman MF. Immunofluorescence of autoimmune bullous diseases. Surg Pathol Clin. 2017;10(2):505-512.
Sárdy M, Kostaki D, Varga R, Peris K, Ruzicka T. Comparative study of direct and indirect immunofluorescence and of bullous pemphigoid 180 and 230 enzyme-linked immunosorbent assays for diagnosis of bullous pemphigoid. J Am Acad Dermatol. 2013;69(5):748-753.
Antiga E, Caproni M. The diagnosis and treatment of dermatitis herpetiformis. Clin Cosmet Investig Dermatol. 2015;8:257-265.