Microbial recognition regulates intestinal epithelial growth in homeostasis and disease.
IMD
NOD
TLR
disease
growth
homeostasis
immunity
intestine
microbe
stem cells
Journal
The FEBS journal
ISSN: 1742-4658
Titre abrégé: FEBS J
Pays: England
ID NLM: 101229646
Informations de publication
Date de publication:
07 2022
07 2022
Historique:
revised:
06
04
2021
received:
18
12
2020
accepted:
30
04
2021
pubmed:
13
5
2021
medline:
9
7
2022
entrez:
12
5
2021
Statut:
ppublish
Résumé
The intestine is constantly exposed to a dynamic community of microbes. Intestinal epithelial cells respond to microbes through evolutionarily conserved recognition pathways, such as the immune deficiency (IMD) pathway of Drosophila, the Toll-like receptor (TLR) response of flies and vertebrates, and the vertebrate nucleotide-binding oligomerization domain (NOD) pathway. Microbial recognition pathways are tightly controlled to respond effectively to pathogens, tolerate the microbiome, and limit intestinal disease. In this review, we focus on contributions of different model organisms to our understanding of how epithelial microbe recognition impacts intestinal proliferation and differentiation in homeostasis and disease. In particular, we compare how microbes and subsequent recognition by the intestine influences barrier integrity, intestinal repair and tumorigenesis in Drosophila, zebrafish, mice, and organoids. In addition, we discuss the importance of microbial recognition in homeostatic intestinal growth and discuss how immune pathways directly impact stem cell and crypt dynamics.
Substances chimiques
Toll-Like Receptors
0
Types de publication
Journal Article
Review
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
3666-3691Subventions
Organisme : CIHR
ID : PJT 159604
Pays : Canada
Informations de copyright
© 2021 Federation of European Biochemical Societies.
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