BLI
CEST MRI
biodegradation
gelatin
glial-restricted progenitor
hyaluronic acid
hydrogel
Journal
ACS applied materials & interfaces
ISSN: 1944-8252
Titre abrégé: ACS Appl Mater Interfaces
Pays: United States
ID NLM: 101504991
Informations de publication
Date de publication:
26 May 2021
26 May 2021
Historique:
pubmed:
13
5
2021
medline:
24
8
2021
entrez:
12
5
2021
Statut:
ppublish
Résumé
Transplanted glial-restricted progenitor (GRP) cells have potential to focally replace defunct astrocytes and produce remyelinating oligodendrocytes to avert neuronal death and dysfunction. However, most central nervous system cell therapeutic paradigms are hampered by high initial cell death and a host anti-graft immune response. We show here that composite hyaluronic acid-based hydrogels of tunable mechanical strengths can significantly improve transplanted GRP survival and differentiation. Allogeneic GRPs expressing green fluorescent protein and firefly luciferase were scaffolded in optimized hydrogel formulations and transplanted intracerebrally into immunocompetent BALB/c mice followed by serial
Identifiants
pubmed: 33978398
doi: 10.1021/acsami.1c03415
pmc: PMC9440547
mid: NIHMS1832114
doi:
Substances chimiques
Hydrogels
0
Hyaluronic Acid
9004-61-9
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
23423-23437Subventions
Organisme : NIBIB NIH HHS
ID : R01 EB023647
Pays : United States
Organisme : NIBIB NIH HHS
ID : R21 EB026711
Pays : United States
Organisme : NIH HHS
ID : S10 OD010744
Pays : United States
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