A Global Vista of the Epigenomic State of the Mouse Submandibular Gland.
ChIP-sequencing
epigenomics
gene expression
histone modification
regulatory regions
salivary glands
Journal
Journal of dental research
ISSN: 1544-0591
Titre abrégé: J Dent Res
Pays: United States
ID NLM: 0354343
Informations de publication
Date de publication:
12 2021
12 2021
Historique:
pubmed:
13
5
2021
medline:
27
1
2022
entrez:
12
5
2021
Statut:
ppublish
Résumé
The parotid, submandibular, and sublingual glands represent a trio of oral secretory glands whose primary function is to produce saliva, facilitate digestion of food, provide protection against microbes, and maintain oral health. While recent studies have begun to shed light on the global gene expression patterns and profiles of salivary glands, particularly those of mice, relatively little is known about the location and identity of transcriptional control elements. Here we have established the epigenomic landscape of the mouse submandibular salivary gland (SMG) by performing chromatin immunoprecipitation sequencing experiments for 4 key histone marks. Our analysis of the comprehensive SMG data sets and comparisons with those from other adult organs have identified critical enhancers and super-enhancers of the mouse SMG. By further integrating these findings with complementary RNA-sequencing based gene expression data, we have unearthed a number of molecular regulators such as members of the
Identifiants
pubmed: 33978512
doi: 10.1177/00220345211012000
pmc: PMC8640340
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
1492-1500Subventions
Organisme : NIDCR NIH HHS
ID : R01 DE027660
Pays : United States
Organisme : NIDCR NIH HHS
ID : T32 DE023526
Pays : United States
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