Expanding the Limits of Liver Transplantation for Hepatocellular Carcinoma: Is There a Limit?

Carcinoma, Hepatocellular / pathology Humans Liver Neoplasms / pathology Liver Transplantation Neoplasm Recurrence, Local Neoplasm Staging Patient Selection
Hepatocellular carcinoma Liver transplantation Organ allocation Organ utility Survival benefit Survival threshold

Journal

Clinics in liver disease
ISSN: 1557-8224
Titre abrégé: Clin Liver Dis
Pays: United States
ID NLM: 9710002

Informations de publication

Date de publication:
02 2021
Historique:
entrez: 12 5 2021
pubmed: 13 5 2021
medline: 26 10 2021
Statut: ppublish

Résumé

Liver transplantation is a treatment option for hepatocellular carcinoma within Milan criteria. With careful selection practices, patients with larger tumors can do well with successful downstaging followed by liver transplantation and should not be excluded based on tumor size or number alone. When considering expanded criteria for hepatocellular carcinoma, however, survival outcomes after liver transplantation should be comparable with patients without hepatocellular carcinoma. Surrogate measures of tumor biology, such as α-fetoprotein, other biomarkers, and dynamic tumor behavior including response to locoregional therapy can aid in risk stratification of patients before liver transplantation.

Identifiants

DOI: 10.1016/j.cld.2020.08.002 PMID: 33978578
pubmed: 33978578
pii: S1089-3261(20)30066-0
doi: 10.1016/j.cld.2020.08.002
pii:
doi:

Types de publication

Journal Article Research Support, N.I.H., Extramural Review

Langues

eng

Sous-ensembles de citation

IM

Pagination

19-33

Subventions

Organisme : NIAID NIH HHS
ID : R25 AI147369
Pays : United States

Informations de copyright

Copyright © 2020 Elsevier Inc. All rights reserved.

Déclaration de conflit d'intérêts

Disclosure The authors have nothing to disclose.

Auteurs

Allison Kwong (A)

Division of Gastroenterology and Hepatology, Stanford University, 420 Broadway Street, 3rd Floor, Redwood City, CA 94063, USA.

Neil Mehta (N)

Division of Gastroenterology, University of California, San Francisco, 513 Parnassus Avenue, S-357, San Francisco, CA 94143, USA. Electronic address: neil.mehta@stanford.edu.

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Classifications MeSH

questionsmedicales.fr › Maladies de l'appareil digestif › Maladies du foie › Tumeurs du foie › Carcinome hépatocellulaire › Expanding the Limits of Liver Transplantation...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Expanding the Limits of Liver Transplantation...
questionsmedicales.fr › Maladies de l'appareil digestif › Maladies du foie › Tumeurs du foie › Expanding the Limits of Liver Transplantation...
questionsmedicales.fr › Procédures de chirurgie opératoire › Transplantation › Transplantation de tissu › Transplantation hépatique › Expanding the Limits of Liver Transplantation...
questionsmedicales.fr › États, signes et symptômes pathologiques › Processus pathologiques › Processus néoplasiques › Récidive tumorale locale › Expanding the Limits of Liver Transplantation...
questionsmedicales.fr › Diagnostic › Pronostic › Stadification tumorale › Expanding the Limits of Liver Transplantation...
questionsmedicales.fr › Administration des services de santé › Gestion des soins aux patients › Sélection de patients › Expanding the Limits of Liver Transplantation...