Contrast-enhanced ultrasound of the pediatric bowel.
Bowel
Children
Contrast-enhanced ultrasound
Crohn disease
Inflammatory bowel disease
Ultrasound
Ultrasound contrast agents
Journal
Pediatric radiology
ISSN: 1432-1998
Titre abrégé: Pediatr Radiol
Pays: Germany
ID NLM: 0365332
Informations de publication
Date de publication:
Nov 2021
Nov 2021
Historique:
received:
11
06
2020
accepted:
30
09
2020
revised:
13
08
2020
pubmed:
13
5
2021
medline:
10
11
2021
entrez:
12
5
2021
Statut:
ppublish
Résumé
Contrast-enhanced ultrasound (CEUS) has emerged as a valuable modality for bowel imaging in adults and children. CEUS enables visualization of the perfusion of the bowel wall and of the associated mesentery in healthy and disease states. In addition, CEUS images can be used to make quantitative measurements of contrast kinetics, allowing for objective assessment of bowel wall enhancement. Bowel CEUS is commonly applied to evaluate inflammatory bowel disease and to monitor treatment response. It has also been applied to evaluate necrotizing enterocolitis, intussusception, appendicitis and epiploic appendagitis, although experience with these applications is more limited. In this review article, we present the current experience using CEUS to evaluate the pediatric bowel with emphasis on inflammatory bowel disease, extrapolating the established experience from adult studies. We also discuss emerging applications of CEUS as an adjunct or problem-solving tool for evaluating bowel perfusion.
Identifiants
pubmed: 33978797
doi: 10.1007/s00247-020-04868-x
pii: 10.1007/s00247-020-04868-x
pmc: PMC8113288
doi:
Substances chimiques
Contrast Media
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
2214-2228Informations de copyright
© 2021. Springer-Verlag GmbH Germany, part of Springer Nature.
Références
Medellin A, Merrill C, Wilson SR (2018) Role of contrast-enhanced ultrasound in evaluation of the bowel. Abdom Radiol 43:918–933
doi: 10.1007/s00261-017-1399-6
Pecere S, Holleran G, Ainora ME et al (2018) Usefulness of contrast-enhanced ultrasound (CEUS) in inflammatory bowel disease (IBD). Dig Liver Dis 50:761–767
pubmed: 29705029
doi: 10.1016/j.dld.2018.03.023
Ripolles T, Martinez-Perez MJ, Blanc E et al (2011) Contrast-enhanced ultrasound (CEUS) in Crohn's disease: technique, image interpretation and clinical applications. Insights Imaging 2:639–652
pubmed: 22347983
pmcid: 3259412
doi: 10.1007/s13244-011-0124-1
Serafin Z, Bialecki M, Bialecka A et al (2016) Contrast-enhanced ultrasound for detection of Crohn's disease activity: systematic review and meta-analysis. J Crohns Colitis 10:354–362
pubmed: 26507861
doi: 10.1093/ecco-jcc/jjv196
Ma X, Li Y, Jia H et al (2015) Contrast-enhanced ultrasound in the diagnosis of patients suspected of having active Crohn's disease: meta-analysis. Ultrasound Med Biol 41:659–668
pubmed: 25619783
doi: 10.1016/j.ultrasmedbio.2014.09.013
Incesu L, Yazicioglu AK, Selcuk MB, Ozen N (2004) Contrast-enhanced power Doppler US in the diagnosis of acute appendicitis. Eur J Radiol 50:201–209
pubmed: 15081132
doi: 10.1016/S0720-048X(03)00102-5
Gorg C, Egbring J, Bert T (2009) Contrast-enhanced ultrasound of epiploic appendagitis. Ultraschall Med 30:163–167
pubmed: 19253206
doi: 10.1055/s-2008-1027891
Rafailidis V, Phillips C, Yusuf G, Sidhu P (2017) A case of adult intussusception with greyscale, contrast-enhanced ultrasound and computerised tomography correlation. Ultrasound 25:120–125
pubmed: 28567107
doi: 10.1177/1742271X16678646
Mudambi K, Sandberg J, Bass D, Rubesova E (2020) Contrast enhanced ultrasound: comparing a novel modality to MRI to assess for bowel disease in pediatric Crohn's patients. Transl Gastroenterol Hepatol 5:13
pubmed: 32258517
pmcid: 7063494
doi: 10.21037/tgh.2019.11.02
Benjamin JL, Dennis R, White S Jr et al (2020) Improved diagnostic sensitivity of bowel disease of prematurity on contrast-enhanced ultrasound. J Ultrasound Med 39:1031–1036
pubmed: 31705672
doi: 10.1002/jum.15168
Thimm MA, Cuffari C, Garcia A et al (2019) Contrast-enhanced ultrasound and shear wave elastography evaluation of Crohn's disease activity in three adolescent patients. Pediatr Gastroenterol Hepatol Nutr 22:282–290
pubmed: 31110961
pmcid: 6506424
doi: 10.5223/pghn.2019.22.3.282
Kljucevsek D, Vidmar D, Urlep D, Dezman R (2016) Dynamic contrast-enhanced ultrasound of the bowel wall with quantitative assessment of Crohn's disease activity in childhood. Radiol Oncol 50:347–354
pubmed: 27904441
pmcid: 5120573
doi: 10.1515/raon-2015-0042
Zezos P, Zittan E, Islam S et al (2019) Associations between quantitative evaluation of bowel wall microvascular flow by contrast-enhanced ultrasound and indices of disease activity in Crohn's disease patients using both bolus and infusion techniques. J Clin Ultrasound 47:453–460
pubmed: 31343081
doi: 10.1002/jcu.22763
Martinez MJ, Ripolles T, Paredes JM et al (2019) Intravenous contrast-enhanced ultrasound for assessing and grading postoperative recurrence of Crohn's disease. Dig Dis Sci 64:1640–1650
pubmed: 30604372
doi: 10.1007/s10620-018-5432-6
Wilkens R, Hagemann-Madsen RH, Peters DA et al (2018) Validity of contrast-enhanced ultrasonography and dynamic contrast-enhanced MR enterography in the assessment of transmural activity and fibrosis in Crohn's disease. J Crohns Colitis 12:48–56
pubmed: 28981627
doi: 10.1093/ecco-jcc/jjx111
Goertz RS, Klett D, Wildner D et al (2018) Quantitative contrast-enhanced ultrasound for monitoring vedolizumab therapy in inflammatory bowel disease patients: a pilot study. Acta Radiol 59:1149–1156
pubmed: 29345146
doi: 10.1177/0284185117752032
Giannetti A, Matergi M, Biscontri M, Franci L (2017) Contrast-enhanced ultrasonography in clinical practice in Crohn's disease: feasibility of destruction/replenishment method and software analysis. J Ultrasound 20:309–319
pubmed: 29204235
pmcid: 5698187
doi: 10.1007/s40477-017-0263-4
Coelho R, Ribeiro H, Maconi G (2017) Bowel thickening in Crohn's disease: fibrosis or inflammation? Diagnostic ultrasound imaging tools. Inflamm Bowel Dis 23:23–34
pubmed: 28002125
doi: 10.1097/MIB.0000000000000997
Quaia E, Cabibbo B, De Paoli L et al (2013) The value of time-intensity curves obtained after microbubble contrast agent injection to discriminate responders from non-responders to anti-inflammatory medication among patients with Crohn's disease. Eur Radiol 23:1650–1659
pubmed: 23306710
doi: 10.1007/s00330-012-2754-1
Liu C, Xu XR, Xu HX et al (2015) Conventional ultrasound and contrast-enhanced ultrasound in evaluating the severity of Crohn's disease. Int J Clin Exp Med 8:123–134
pubmed: 25784981
pmcid: 4358436
Nylund K, Jirik R, Mezl M et al (2013) Quantitative contrast-enhanced ultrasound comparison between inflammatory and fibrotic lesions in patients with Crohn's disease. Ultrasound Med Biol 39:1197–1206
pubmed: 23643057
doi: 10.1016/j.ultrasmedbio.2013.01.020
Romanini L, Passamonti M, Navarria M et al (2014) Quantitative analysis of contrast-enhanced ultrasonography of the bowel wall can predict disease activity in inflammatory bowel disease. Eur J Radiol 83:1317–1323
pubmed: 24908589
doi: 10.1016/j.ejrad.2014.05.012
Saevik F, Nylund K, Hausken T et al (2014) Bowel perfusion measured with dynamic contrast-enhanced ultrasound predicts treatment outcome in patients with Crohn's disease. Inflamm Bowel Dis 20:2029–2037
pubmed: 25185684
doi: 10.1097/MIB.0000000000000159
Wong DD, Forbes GM, Zelesco M et al (2012) Crohn's disease activity: quantitative contrast-enhanced ultrasound assessment. Abdom Imaging 37:369–376
pubmed: 21830051
doi: 10.1007/s00261-011-9792-z
Ripolles T, Martinez-Perez MJ, Paredes JM et al (2013) Contrast-enhanced ultrasound in the differentiation between phlegmon and abscess in Crohn's disease and other abdominal conditions. Eur J Radiol 82:e525–e531
pubmed: 23838329
doi: 10.1016/j.ejrad.2013.05.043
Mao R, Chen YJ, Chen BL et al (2018) Intra-cavitary contrast-enhanced ultrasound: a novel radiation-free method to detect abscess associated penetrating disease in Crohn's disease. J Crohns Colitis 13:593–599
doi: 10.1093/ecco-jcc/jjy209
Kljucevsek D, Riccabona M, Ording Muller LS et al (2020) Intracavitary contrast-enhanced ultrasonography in children: review with procedural recommendations and clinical applications from the European Society of Paediatric Radiology abdominal imaging task force. Pediatr Radiol 50:596–606
pubmed: 32055916
doi: 10.1007/s00247-019-04611-1
Menozzi G, Maccabruni V, Zanichelli M, Massari M (2014) Contrast-enhanced ultrasound appearance of primary epiploic appendagitis. J Ultrasound 17:75–76
pubmed: 24616754
pmcid: 3945196
doi: 10.1007/s40477-014-0073-x
Atkinson NSS, Bryant RV, Dong Y et al (2017) How to perform gastrointestinal ultrasound: anatomy and normal findings. World J Gastroenterol 23:6931–6941
pubmed: 29097866
pmcid: 5658311
doi: 10.3748/wjg.v23.i38.6931
Gale HI, Gee MS, Westra SJ, Nimkin K (2016) Abdominal ultrasonography of the pediatric gastrointestinal tract. World J Radiol 8:656–667
pubmed: 27551336
pmcid: 4965350
doi: 10.4329/wjr.v8.i7.656
Sidhu PS, Cantisani V, Dietrich CF et al (2018) The EFSUMB guidelines and recommendations for the clinical practice of contrast-enhanced ultrasound (CEUS) in non-hepatic applications: update 2017 (long version). Ultraschall Med 39:e2–e44
pubmed: 29510439
doi: 10.1055/a-0586-1107
Ripolles T, Martinez-Perez MJ, Paredes JM et al (2019) The role of intravenous contrast agent in the sonographic assessment of Crohn's disease activity: is contrast agent injection necessary? J Crohns Colitis 13:585–592
pubmed: 30535070
doi: 10.1093/ecco-jcc/jjy204
Wilkens R, Wilson A, Burns PN et al (2018) Persistent enhancement on contrast-enhanced ultrasound studies of severe Crohn's disease: stuck bubbles? Ultrasound Med Biol 44:2189–2198
pubmed: 30076030
doi: 10.1016/j.ultrasmedbio.2018.06.018
Bialecki M, Bialecka A, Laskowska K et al (2014) Contrast-enhanced ultrasonography for the determination of Crohn's disease activity — preliminary experience. Pol J Radiol 79:70–74
Ripolles T, Rausell N, Paredes JM et al (2013) Effectiveness of contrast-enhanced ultrasound for characterisation of intestinal inflammation in Crohn's disease: a comparison with surgical histopathology analysis. J Crohns Colitis 7:120–128
pubmed: 22483566
doi: 10.1016/j.crohns.2012.03.002
Quaia E (2013) Contrast-enhanced ultrasound of the small bowel in Crohn's disease. Abdom Imaging 38:1005–1013
pubmed: 23728306
doi: 10.1007/s00261-013-0014-8
Paredes JM, Ripolles T, Cortes X et al (2013) Contrast-enhanced ultrasonography: usefulness in the assessment of postoperative recurrence of Crohn's disease. J Crohns Colitis 7:192–201
pubmed: 22542055
doi: 10.1016/j.crohns.2012.03.017
Ripolles T, Martinez MJ, Paredes JM et al (2009) Crohn disease: correlation of findings at contrast-enhanced US with severity at endoscopy. Radiology 253:241–248
pubmed: 19635834
doi: 10.1148/radiol.2531082269
Migaleddu V, Scanu AM, Quaia E et al (2009) Contrast-enhanced ultrasonographic evaluation of inflammatory activity in Crohn's disease. Gastroenterology 137:43–52
pubmed: 19422826
doi: 10.1053/j.gastro.2009.03.062
Quaia E, Gennari AG, Cova MA, van Beek EJR (2018) Differentiation of inflammatory from fibrotic ileal strictures among patients with Crohn's disease based on visual analysis: feasibility study combining conventional B-mode ultrasound, contrast-enhanced ultrasound and strain elastography. Ultrasound Med Biol 44:762–770
pubmed: 29331357
doi: 10.1016/j.ultrasmedbio.2017.11.015
Braden B, Ignee A, Hocke M et al (2010) Diagnostic value and clinical utility of contrast enhanced ultrasound in intestinal diseases. Dig Liver Dis 42:667–674
pubmed: 20598952
doi: 10.1016/j.dld.2010.05.018
Serra C, Menozzi G, Labate AM et al (2007) Ultrasound assessment of vascularization of the thickened terminal ileum wall in Crohn's disease patients using a low-mechanical index real-time scanning technique with a second generation ultrasound contrast agent. Eur J Radiol 62:114–121
pubmed: 17239555
doi: 10.1016/j.ejrad.2006.11.027
De Pascale A, Garofalo G, Perna M et al (2006) Contrast-enhanced ultrasonography in Crohn's disease. Radiol Med 111:539–550
pubmed: 16779540
doi: 10.1007/s11547-006-0049-9
Robotti D, Cammarota T, Debani P et al (2004) Activity of Crohn disease: value of color-power-Doppler and contrast-enhanced ultrasonography. Abdom Imaging 29:648–652
pubmed: 15162232
doi: 10.1007/s00261-003-0157-0
Piscaglia F, Nolsoe C, Dietrich CF et al (2012) The EFSUMB guidelines and recommendations on the clinical practice of contrast enhanced ultrasound (CEUS): update 2011 on non-hepatic applications. Ultraschall Med 33:33–59
pubmed: 21874631
doi: 10.1055/s-0031-1281676
Campani R, Calliada F, Bottinelli O et al (1998) Contrast enhancing agents in ultrasonography: clinical applications. Eur J Radiol 27:S161–S170
pubmed: 9652517
doi: 10.1016/S0720-048X(98)00058-8
van Wassenaer EA, de Voogd FAE, van Rijn RR et al (2020) Bowel ultrasound measurements in healthy children — systematic review and meta-analysis. Pediatr Radiol 50:501–508
pubmed: 31838567
doi: 10.1007/s00247-019-04567-2
Chiorean L, Schreiber-Dietrich D, Braden B et al (2014) Transabdominal ultrasound for standardized measurement of bowel wall thickness in normal children and those with Crohn's disease. Med Ultrason 16:319–324
pubmed: 25463885
Quaia E, Migaleddu V, Baratella E et al (2009) The diagnostic value of small bowel wall vascularity after sulfur hexafluoride-filled microbubble injection in patients with Crohn's disease. Correlation with the therapeutic effectiveness of specific anti-inflammatory treatment. Eur J Radiol 69:438–444
pubmed: 19070446
doi: 10.1016/j.ejrad.2008.10.029
Ponder A, Long MD (2013) A clinical review of recent findings in the epidemiology of inflammatory bowel disease. Clin Epidemiol 5:237–247
pubmed: 23922506
pmcid: 3728155
Danese S, Fiocchi C (2011) Ulcerative colitis. N Engl J Med 365:1713–1725
pubmed: 22047562
doi: 10.1056/NEJMra1102942
Quaia E, De Paoli L, Stocca T et al (2012) The value of small bowel wall contrast enhancement after sulfur hexafluoride-filled microbubble injection to differentiate inflammatory from fibrotic strictures in patients with Crohn's disease. Ultrasound Med Biol 38:1324–1332
pubmed: 22698508
doi: 10.1016/j.ultrasmedbio.2012.04.008
Di Sabatino A, Fulle I, Ciccocioppo R et al (2002) Doppler enhancement after intravenous Levovist injection in Crohn's disease. Inflamm Bowel Dis 8:251–257
pubmed: 12131608
doi: 10.1097/00054725-200207000-00003
Girlich C, Jung EM, Huber E et al (2011) Comparison between preoperative quantitative assessment of bowel wall vascularization by contrast-enhanced ultrasound and operative macroscopic findings and results of histopathological scoring in Crohn's disease. Ultraschall Med 32:154–159
pubmed: 20449794
doi: 10.1055/s-0029-1245398
Schreyer AG, Finkenzeller T, Gossmann H et al (2008) Microcirculation and perfusion with contrast enhanced ultrasound (CEUS) in Crohn's disease: first results with linear contrast harmonic imaging (CHI). Clin Hemorheol Microcirc 40:143–155
pubmed: 19029639
doi: 10.3233/CH-2008-1125
Mansuri I, Fletcher JG, Bruining DH et al (2017) Endoscopic skipping of the terminal ileum in pediatric Crohn disease. AJR Am J Roentgenol 208:W216–W224
pubmed: 28379745
doi: 10.2214/AJR.16.16575
Dillman JR, Rubin JM, Johnson LA et al (2017) Can contrast-enhanced sonography detect bowel wall fibrosis in mixed inflammatory and fibrotic Crohn disease lesions in an animal model? J Ultrasound Med 36:523–530
pubmed: 28072481
pmcid: 6557400
doi: 10.7863/ultra.16.04064
Abraham BP, Mehta S, El-Serag HB (2012) Natural history of pediatric-onset inflammatory bowel disease: a systematic review. J Clin Gastroenterol 46:581–589
pubmed: 22772738
pmcid: 3972042
doi: 10.1097/MCG.0b013e318247c32f
Rosen MJ, Dhawan A, Saeed SA (2015) Inflammatory bowel disease in children and adolescents. JAMA Pediatr 169:1053–1060
pubmed: 26414706
pmcid: 4702263
doi: 10.1001/jamapediatrics.2015.1982
Benchimol EI, Fortinsky KJ, Gozdyra P et al (2011) Epidemiology of pediatric inflammatory bowel disease: a systematic review of international trends. Inflamm Bowel Dis 17:423–439
pubmed: 20564651
doi: 10.1002/ibd.21349
Oliveira SB, Monteiro IM (2017) Diagnosis and management of inflammatory bowel disease in children. BMJ 357:j2083
pubmed: 28566467
pmcid: 6888256
doi: 10.1136/bmj.j2083
Gasparetto M, Guariso G, Pozza LV et al (2016) Clinical course and outcomes of diagnosing inflammatory bowel disease in children 10 years and under: retrospective cohort study from two tertiary centres in the United Kingdom and in Italy. BMC Gastroenterol 16:35
pubmed: 26976427
pmcid: 4791934
doi: 10.1186/s12876-016-0455-y
Horn CB, Tian D, Bochicchio GV, Turnbull IR (2018) Incidence, demographics, and outcomes of nonoperative management of appendicitis in the United States. J Surg Res 223:251–258
pubmed: 29198605
doi: 10.1016/j.jss.2017.10.007
Zhang F, Miao LY, Ge HY et al (2018) Usefulness of contrast-enhanced ultrasound in differentiating inflammatory bowel disease from colon cancer. Ultrasound Med Biol 44:124–133
pubmed: 29126753
doi: 10.1016/j.ultrasmedbio.2017.09.016
Lin PW, Stoll BJ (2006) Necrotising enterocolitis. Lancet 368:1271–1283
pubmed: 17027734
doi: 10.1016/S0140-6736(06)69525-1
Epelman M, Daneman A, Navarro OM et al (2007) Necrotizing enterocolitis: review of state-of-the-art imaging findings with pathologic correlation. Radiographics 27:285–305
pubmed: 17374854
doi: 10.1148/rg.272055098
Al-Hamad S, Hackam DJ, Goldstein SD et al (2018) Contrast-enhanced ultrasound and near-infrared spectroscopy of the neonatal bowel: novel, bedside, noninvasive, and radiation-free imaging for early detection of necrotizing enterocolitis. Am J Perinatol 35:1358–1365
pubmed: 29852509
doi: 10.1055/s-0038-1655768