FRET-Integrated Polymer Brushes for Spatially Resolved Sensing of Changes in Polymer Conformation.
FRET
chemosensing
fluorescence
polymer brushes
polymer dynamics
Journal
Angewandte Chemie (International ed. in English)
ISSN: 1521-3773
Titre abrégé: Angew Chem Int Ed Engl
Pays: Germany
ID NLM: 0370543
Informations de publication
Date de publication:
19 07 2021
19 07 2021
Historique:
received:
25
03
2021
pubmed:
13
5
2021
medline:
13
5
2021
entrez:
12
5
2021
Statut:
ppublish
Résumé
Polymer brush surfaces that alter their physical properties in response to chemical stimuli have the capacity to be used as new surface-based sensing materials. For such surfaces, detecting the polymer conformation is key to their sensing capabilities. Herein, we report on FRET-integrated ultrathin (<70 nm) polymer brush surfaces that exhibit stimuli-dependent FRET with changing brush conformation. Poly(N-isopropylacrylamide) polymers were chosen due their exceptional sensitivity to liquid mixture compositions and their ability to be assembled into well-defined polymer brushes. The brush transitions were used to optically sense changes in liquid mixture compositions with high spatial resolution (tens of micrometers), where the FRET coupling allowed for noninvasive observation of brush transitions around complex interfaces with real-time sensing of the liquid environment. Our methods have the potential to be leveraged towards greater surface-based sensing capabilities at intricate interfaces.
Identifiants
pubmed: 33979032
doi: 10.1002/anie.202104204
pmc: PMC8361709
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
16600-16606Informations de copyright
© 2021 The Authors. Angewandte Chemie International Edition published by Wiley-VCH GmbH.
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