Bioengineering in vitro models of embryonic development.
3D matrix
bioengineering
blastoids
embryonic development
gastruloids
in vitro models
microfluidics
optogenetics
organoids
stem cells
Journal
Stem cell reports
ISSN: 2213-6711
Titre abrégé: Stem Cell Reports
Pays: United States
ID NLM: 101611300
Informations de publication
Date de publication:
11 05 2021
11 05 2021
Historique:
received:
15
03
2021
revised:
11
04
2021
accepted:
11
04
2021
entrez:
12
5
2021
pubmed:
13
5
2021
medline:
3
3
2022
Statut:
ppublish
Résumé
Stem cell-based in vitro models of embryonic development have been established over the last decade. Such model systems recapitulate aspects of gametogenesis, early embryonic development, or organogenesis. They enable experimental approaches that have not been possible previously and have the potential to greatly reduce the number of animals required for research. However, each model system has its own limitations, with certain aspects, such as morphogenesis and spatiotemporal control of cell fate decisions, diverging from the in vivo counterpart. Targeted bioengineering approaches to provide defined instructive external signals or to modulate internal cellular signals could overcome some of these limitations. Here, we present the latest technical developments and discuss how bioengineering can further advance the optimization and external control of stem cell-based embryo-like structures (ELSs). In vitro models combined with sophisticated bioengineering tools will enable an even more in-depth analysis of embryonic development in the future.
Identifiants
pubmed: 33979597
pii: S2213-6711(21)00200-9
doi: 10.1016/j.stemcr.2021.04.005
pmc: PMC8185467
pii:
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
1104-1116Subventions
Organisme : NIGMS NIH HHS
ID : R35 GM133380
Pays : United States
Informations de copyright
Copyright © 2021 The Authors. Published by Elsevier Inc. All rights reserved.
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