Pathogenic variants in


Journal

Science advances
ISSN: 2375-2548
Titre abrégé: Sci Adv
Pays: United States
ID NLM: 101653440

Informations de publication

Date de publication:
05 2021
Historique:
received: 14 10 2020
accepted: 23 03 2021
entrez: 13 5 2021
pubmed: 14 5 2021
medline: 14 5 2021
Statut: epublish

Résumé

Intellectual disability encompasses a wide spectrum of neurodevelopmental disorders, with many linked genetic loci. However, the underlying molecular mechanism for more than 50% of the patients remains elusive. We describe pathogenic variants in

Identifiants

pubmed: 33980485
pii: 7/20/eabf2066
doi: 10.1126/sciadv.abf2066
pmc: PMC8115915
pii:
doi:

Types de publication

Journal Article Research Support, Non-U.S. Gov't Research Support, N.I.H., Extramural

Langues

eng

Sous-ensembles de citation

IM

Subventions

Organisme : NHGRI NIH HHS
ID : UM1 HG008900
Pays : United States
Organisme : NHLBI NIH HHS
ID : T32 HL007953
Pays : United States
Organisme : NHGRI NIH HHS
ID : R01 HG009141
Pays : United States
Organisme : NINDS NIH HHS
ID : DP2 NS111996
Pays : United States
Organisme : Wellcome Trust
Pays : United Kingdom

Informations de copyright

Copyright © 2021 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works. Distributed under a Creative Commons Attribution NonCommercial License 4.0 (CC BY-NC).

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Auteurs

Dong Li (D)

Center for Applied Genomics, Children's Hospital of Philadelphia, Philadelphia, PA, USA. lid2@email.chop.edu songy2@email.chop.edu.

Qin Wang (Q)

Raymond G. Perelman Center for Cellular and Molecular Therapeutics, Children's Hospital of Philadelphia, Philadelphia, PA, USA.

Naihua N Gong (NN)

Department of Psychiatry, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA.

Alina Kurolap (A)

The Genetics Institute, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel.

Hagit Baris Feldman (HB)

The Genetics Institute, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel.
Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.

Nikolas Boy (N)

Division of Child Neurology and Metabolic Medicine, Center for Child and Adolescent Medicine, University Hospital Heidelberg, Heidelberg, Germany.

Melanie Brugger (M)

Institute of Human Genetics, Technical University Munich, Munich, Germany.
Institute of Human Genetics, University Hospital LMU Munich, Goethestr. 29, Munich, Germany.

Katheryn Grand (K)

Department of Pediatrics, Cedars-Sinai Medical Center, Los Angeles, CA, USA.

Kirsty McWalter (K)

GeneDx, Gaithersburg, MD, USA.

Emma Wakeling (E)

North East Thames Regional Genetic Service, Great Ormond Street Hospital for Children NHS Foundation Trust, London, UK.

Jane Hurst (J)

North East Thames Regional Genetic Service, Great Ormond Street Hospital for Children NHS Foundation Trust, London, UK.

Michael E March (ME)

Center for Applied Genomics, Children's Hospital of Philadelphia, Philadelphia, PA, USA.

Elizabeth J Bhoj (EJ)

Center for Applied Genomics, Children's Hospital of Philadelphia, Philadelphia, PA, USA.

Małgorzata J M Nowaczyk (MJM)

Department of Pathology and Molecular Medicine, McMaster University, Hamilton, Ontario, Canada.

Claudia Gonzaga-Jauregui (C)

Regeneron Genetics Center, Tarrytown, New York, NY, USA.

Mariam Mathew (M)

Institute for Genomic Medicine, Nationwide Children's Hospital, Columbus, OH, USA.

Ashita Dava-Wala (A)

Institute for Genomic Medicine, Nationwide Children's Hospital, Columbus, OH, USA.

Amy Siemon (A)

Department of Pediatrics and Clinical Genetics, Nationwide Children's Hospital, Columbus, OH, USA.

Dennis Bartholomew (D)

Department of Pediatrics and Clinical Genetics, Nationwide Children's Hospital, Columbus, OH, USA.

Yue Huang (Y)

Department of Human Genetics; Division of Medical Genetics, Department of Pediatrics; David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, USA.

Hane Lee (H)

Department of Pathology and Laboratory Medicine; Department of Human Genetics; David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, USA.

Julian A Martinez-Agosto (JA)

Department of Human Genetics; Division of Medical Genetics, Department of Pediatrics; David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, USA.

Eva M C Schwaibold (EMC)

Department of Pathology and Laboratory Medicine; Department of Human Genetics; David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, USA.

Theresa Brunet (T)

Institute of Human Genetics, Technical University Munich, Munich, Germany.

Daniela Choukair (D)

Division of Paediatric Endocrinology and Diabetes, Department of Paediatrics, University Hospital Heidelberg, Heidelberg, Germany.

Lynn S Pais (LS)

Broad Center for Mendelian Genomics, Program in Medical and Population Genetics, Broad Institute of Massachusetts Institute of Technology and Harvard, Cambridge, MA, USA.

Susan M White (SM)

Victorian Clinical Genetics Services, Murdoch Children's Research Institute, Melbourne, Australia.
Department of Paediatrics, University of Melbourne, Melbourne, Australia.

John Christodoulou (J)

Victorian Clinical Genetics Services, Murdoch Children's Research Institute, Melbourne, Australia.
Department of Paediatrics, University of Melbourne, Melbourne, Australia.

Dana Brown (D)

Division of Genetics and Metabolism, Phoenix Children's Hospital, Phoenix, AZ, USA.

Kristin Lindstrom (K)

Division of Genetics and Metabolism, Phoenix Children's Hospital, Phoenix, AZ, USA.

Theresa Grebe (T)

Division of Genetics and Metabolism, Phoenix Children's Hospital, Phoenix, AZ, USA.
College of Medicine, University of Arizona, Phoenix, 475 N. 5th Street, Phoenix, AZ, USA.

Dov Tiosano (D)

Pediatric Endocrinology Unit, Ruth Rappaport Children's Hospital, Rambam Healthcare Campus, Haifa, Israel.
The Ruth and Bruce Rappaport Faculty of Medicine, Technion, Israel Institute of Technology, Haifa, Israel.

Matthew S Kayser (MS)

Department of Psychiatry, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA.

Tiong Yang Tan (TY)

Victorian Clinical Genetics Services, Murdoch Children's Research Institute, Melbourne, Australia.
Department of Paediatrics, University of Melbourne, Melbourne, Australia.

Matthew A Deardorff (MA)

Departments of Pathology and Pediatrics, Children's Hospital Los Angeles, and University of Southern California, Los Angeles, CA, USA.

Yuanquan Song (Y)

Raymond G. Perelman Center for Cellular and Molecular Therapeutics, Children's Hospital of Philadelphia, Philadelphia, PA, USA. lid2@email.chop.edu songy2@email.chop.edu.
Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA, USA.

Hakon Hakonarson (H)

Center for Applied Genomics, Children's Hospital of Philadelphia, Philadelphia, PA, USA.
Department of Pediatrics, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.

Classifications MeSH