Structural evaluation in inherited retinal diseases.
clinical trial
dystrophy
genetics
imaging
retina
Journal
The British journal of ophthalmology
ISSN: 1468-2079
Titre abrégé: Br J Ophthalmol
Pays: England
ID NLM: 0421041
Informations de publication
Date de publication:
12 2021
12 2021
Historique:
received:
05
03
2021
revised:
07
04
2021
accepted:
21
04
2021
pubmed:
14
5
2021
medline:
9
4
2022
entrez:
13
5
2021
Statut:
ppublish
Résumé
Ophthalmic genetics is a field that has been rapidly evolving over the last decade, mainly due to the flourishing of translational medicine for inherited retinal diseases (IRD). In this review, we will address the different methods by which retinal structure can be objectively and accurately assessed in IRD. We review standard-of-care imaging for these patients: colour fundus photography, fundus autofluorescence imaging and optical coherence tomography (OCT), as well as higher-resolution and/or newer technologies including OCT angiography, adaptive optics imaging, fundus imaging using a range of wavelengths, magnetic resonance imaging, laser speckle flowgraphy and retinal oximetry, illustrating their utility using paradigm genotypes with on-going therapeutic efforts/trials.
Identifiants
pubmed: 33980508
pii: bjophthalmol-2021-319228
doi: 10.1136/bjophthalmol-2021-319228
pmc: PMC8639906
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
1623-1631Subventions
Organisme : Wellcome Trust
Pays : United Kingdom
Organisme : Wellcome Trust
ID : 099173/Z/12/Z
Pays : United Kingdom
Organisme : Department of Health
Pays : United Kingdom
Informations de copyright
© Author(s) (or their employer(s)) 2021. Re-use permitted under CC BY. Published by BMJ.
Déclaration de conflit d'intérêts
Competing interests: The authors alone are responsible for the content and writing of this article. MM consults for MeiraGTx.
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