Distinct axial and lateral interactions within homologous filaments dictate the signaling specificity and order of the AIM2-ASC inflammasome.
Journal
Nature communications
ISSN: 2041-1723
Titre abrégé: Nat Commun
Pays: England
ID NLM: 101528555
Informations de publication
Date de publication:
12 05 2021
12 05 2021
Historique:
received:
17
09
2020
accepted:
14
04
2021
entrez:
13
5
2021
pubmed:
14
5
2021
medline:
28
5
2021
Statut:
epublish
Résumé
Inflammasomes are filamentous signaling platforms integral to innate immunity. Currently, little is known about how these structurally similar filaments recognize and distinguish one another. A cryo-EM structure of the AIM2
Identifiants
pubmed: 33980849
doi: 10.1038/s41467-021-23045-8
pii: 10.1038/s41467-021-23045-8
pmc: PMC8115694
doi:
Substances chimiques
AIM2 protein, human
0
CARD Signaling Adaptor Proteins
0
DNA-Binding Proteins
0
Inflammasomes
0
PYCARD protein, human
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.
Langues
eng
Sous-ensembles de citation
IM
Pagination
2735Subventions
Organisme : NIGMS NIH HHS
ID : R01 GM129342
Pays : United States
Organisme : NIGMS NIH HHS
ID : R35 GM122510
Pays : United States
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