Resting mononuclear cell NR3C1 and SKA2 expression levels predict blunted cortisol reactivity to combat training stress among elite army cadets exposed to childhood adversity.
Journal
Molecular psychiatry
ISSN: 1476-5578
Titre abrégé: Mol Psychiatry
Pays: England
ID NLM: 9607835
Informations de publication
Date de publication:
11 2021
11 2021
Historique:
received:
05
01
2021
accepted:
07
04
2021
revised:
16
03
2021
pubmed:
14
5
2021
medline:
15
3
2022
entrez:
13
5
2021
Statut:
ppublish
Résumé
Childhood adversity (CA) may alter reactivity to stress throughout life, increasing risk for psychiatric and medical morbidity, yet long-term correlates of milder CA levels among high functioning healthy adolescents are less studied. The current study examined the prevalence and impact of CA exposure among a cohort of healthy motivated elite parachute unit volunteers, prospectively assessed at rest and at the height of an intensive combat-simulation exposure. We found significantly reduced gene expression levels in resting mononuclear cell nuclear receptor, subfamily 3, member 1 (NR3C1), and its transactivator spindle and kinetochore-associated protein 2 (SKA2), that predict blunted cortisol reactivity to combat-simulation stress among CA exposed adolescents. Long-term alterations in endocrine immune indices, subjective distress, and executive functions persist among healthy high functioning adolescents following milder CA exposure, and may promote resilience or vulnerability to later real-life combat exposure.
Identifiants
pubmed: 33981010
doi: 10.1038/s41380-021-01107-z
pii: 10.1038/s41380-021-01107-z
doi:
Substances chimiques
Chromosomal Proteins, Non-Histone
0
NR3C1 protein, human
0
Receptors, Glucocorticoid
0
SKA2 protein, human
0
Hydrocortisone
WI4X0X7BPJ
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
6680-6687Informations de copyright
© 2021. The Author(s), under exclusive licence to Springer Nature Limited.
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