Amyloid-β Oligomers Induce Only Mild Changes to Inhibitory Bouton Dynamics.
Amyloidosis models
hyperexcitability
inhibitory synapses
presynaptic boutons
structural plasticity
two-photon imaging
Journal
Journal of Alzheimer's disease reports
ISSN: 2542-4823
Titre abrégé: J Alzheimers Dis Rep
Pays: Netherlands
ID NLM: 101705500
Informations de publication
Date de publication:
27 Feb 2021
27 Feb 2021
Historique:
entrez:
13
5
2021
pubmed:
14
5
2021
medline:
14
5
2021
Statut:
epublish
Résumé
The amyloid-β protein precursor is highly expressed in a subset of inhibitory neuron in the hippocampus, and inhibitory neurons have been suggested to play an important role in early Alzheimer's disease plaque load. Here we investigated bouton dynamics in axons of hippocampal interneurons in two independent amyloidosis models. Short-term (24 h) amyloid-β (Aβ)-oligomer application to organotypic hippocampal slices slightly increased inhibitory bouton dynamics, but bouton density and dynamics were unchanged in hippocampus slices of young-adult
Identifiants
pubmed: 33981952
doi: 10.3233/ADR-200291
pii: ADR200291
pmc: PMC8075564
doi:
Types de publication
Journal Article
Langues
eng
Pagination
153-160Informations de copyright
© 2021 – The authors. Published by IOS Press.
Déclaration de conflit d'intérêts
The authors have no conflict of interest to report.
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