Degradation-triggered release from biodegradable metallic surfaces.

biodegradable metals controlled release degradation-driven release iron zinc

Journal

Journal of biomedical materials research. Part B, Applied biomaterials
ISSN: 1552-4981
Titre abrégé: J Biomed Mater Res B Appl Biomater
Pays: United States
ID NLM: 101234238

Informations de publication

Date de publication:
12 2021
Historique:
revised: 14 04 2021
received: 31 12 2020
accepted: 03 05 2021
pubmed: 14 5 2021
medline: 1 4 2022
entrez: 13 5 2021
Statut: ppublish

Résumé

This work is dedicated to the investigation of drug-release control by a direct effect of degradation from biodegradable metallic surfaces. Degradation behaviors characterized by surface morphology, immersion, and electrochemical techniques demonstrated that curcumin-coated zinc (c-Zn) had a higher degradation rate compared to curcumin-coated Fe (c-Fe). High anodic dissolution rate due to the higher degradation rate and widely extended groove-like degradation structure of c-Zn propelled a higher curcumin release. On the other hand, a slower curcumin release rate shown by c-Fe scaffolds is ascribed to its lower anodic dissolution and to its pitting degradation regime with relatively smaller pits. These findings illuminate the remarkable advantage of different degradation behaviors of degradable metallic surfaces in directly controlling the drug release without the need for external electrical stimulus.

Identifiants

pubmed: 33983686
doi: 10.1002/jbm.b.34866
doi:

Substances chimiques

Alloys 0
Biocompatible Materials 0
Zinc J41CSQ7QDS

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

2184-2198

Informations de copyright

© 2021 Wiley Periodicals LLC.

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Auteurs

Abdul Hakim Md Yusop (AH)

Center for Sustainable Nanomaterials, Ibnu Sina Institute for Scientific and Industrial Research, Universiti Teknologi Malaysia, Skudai, Johor, Malaysia.

Ahmed Alsakkaf (A)

School of Mechanical Engineering, Universiti Teknologi Malaysia, Skudai, Johor, Malaysia.

Muhammad Azfar Noordin (MA)

School of Mechanical Engineering, Universiti Teknologi Malaysia, Skudai, Johor, Malaysia.

Hasbullah Idris (H)

School of Mechanical Engineering, Universiti Teknologi Malaysia, Skudai, Johor, Malaysia.

Hadi Nur (H)

Center for Sustainable Nanomaterials, Ibnu Sina Institute for Scientific and Industrial Research, Universiti Teknologi Malaysia, Skudai, Johor, Malaysia.
Central Laboratory of Minerals and Advanced Materials, Faculty of Mathematics and Natural Sciences, State University of Malang, Malang, Indonesia.

Fatihhi Szali Januddi (F)

Advanced Facilities Engineering Technology Research Cluster, Facilities Maintenance Engineering Section, Malaysian Institute of Industrial Technology, Universiti Kuala Lumpur, Johor Bahru, Johor, Malaysia.

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