Decoding the organization, dynamics, and function of the 4D genome.
4D genome
cell identity
gene regulation
nuclear architecture
Journal
Developmental cell
ISSN: 1878-1551
Titre abrégé: Dev Cell
Pays: United States
ID NLM: 101120028
Informations de publication
Date de publication:
07 06 2021
07 06 2021
Historique:
received:
21
09
2020
revised:
15
02
2021
accepted:
21
04
2021
pubmed:
14
5
2021
medline:
21
10
2021
entrez:
13
5
2021
Statut:
ppublish
Résumé
Understanding how complex cell-fate decisions emerge at the molecular level is a key challenge in developmental biology. Despite remarkable progress in decoding the contribution of the linear epigenome, how spatial genome architecture functionally informs changes in gene expression remains unclear. In this review, we discuss recent insights in elucidating the molecular landscape of genome folding, emphasizing the multilayered nature of the 3D genome, its importance for gene regulation, and its spatiotemporal dynamics. Finally, we discuss how these new concepts and emergent technologies will enable us to address some of the outstanding questions in development and disease.
Identifiants
pubmed: 33984271
pii: S1534-5807(21)00361-0
doi: 10.1016/j.devcel.2021.04.023
pii:
doi:
Substances chimiques
Chromatin
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
1562-1573Informations de copyright
Copyright © 2021 Elsevier Inc. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of interests The authors declare no competing interests.