Interactions of core cross-linked poly(2-oxazoline) and poly(2-oxazine) micelles with immune cells in human blood.

Humans Micelles Oxazines Oxazoles Polymerization Polymers
Core cross-linked micelle Cyclic imino ether Emulsion polymerisation Immune cell interaction RAFT polymerisation Stealth effect

Journal

Biomaterials
ISSN: 1878-5905
Titre abrégé: Biomaterials
Pays: Netherlands
ID NLM: 8100316

Informations de publication

Date de publication:
07 2021
Historique:
received: 13 11 2020
revised: 14 04 2021
accepted: 15 04 2021
pubmed: 14 5 2021
medline: 29 6 2021
entrez: 13 5 2021
Statut: ppublish

Résumé

Water-soluble poly(cyclic imino ether)s (PCIEs) have emerged as promising biocompatible polymers for nanomedicine applications in recent years. Despite their generally accepted stealth properties, there has been no comprehensive evaluation of their interactions with primary immune cells in human blood. Here we present a library of core cross-linked micelles (CCMs) containing various PCIE shells. Well-defined high molar mass CCMs (M

Identifiants

DOI: 10.1016/j.biomaterials.2021.120843 PMID: 33984635
pubmed: 33984635
pii: S0142-9612(21)00199-X
doi: 10.1016/j.biomaterials.2021.120843
pii:
doi:

Substances chimiques

Micelles 0
Oxazines 0
Oxazoles 0
Polymers 0
poly(2-oxazoline) 0

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

120843

Informations de copyright

Copyright © 2021 Elsevier Ltd. All rights reserved.

Auteurs

Meike N Leiske (MN)

ARC Centre of Excellence in Convergent Bio-Nano Science & Technology, and Drug Delivery, Disposition and Dynamics, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, VIC, 3052, Australia.

May Lai (M)

ARC Centre of Excellence in Convergent Bio-Nano Science & Technology, and Drug Delivery, Disposition and Dynamics, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, VIC, 3052, Australia.

Thakshila Amarasena (T)

ARC Centre of Excellence in Convergent Bio-Nano Science & Technology, The University of Melbourne, Melbourne, Australia; Department of Microbiology and Immunology, Peter Doherty Institute for Infection and Immunity, The University of Melbourne, Melbourne, VIC, 3000, Australia.

Thomas P Davis (TP)

ARC Centre of Excellence in Convergent Bio-Nano Science & Technology, and Drug Delivery, Disposition and Dynamics, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, VIC, 3052, Australia; Centre for Advanced Imaging (CAI) and Australian Institute for Bioengineering and Nanotechnology, ARC Centre of Excellence in Convergent Bio-Nano Science & Technology and ARC Training Centre for Innovation in Biomedical Imaging Technology, The University of Queensland, St. Lucia, QLD, 4072, Australia.

Kristofer J Thurecht (KJ)

Centre for Advanced Imaging (CAI) and Australian Institute for Bioengineering and Nanotechnology, ARC Centre of Excellence in Convergent Bio-Nano Science & Technology and ARC Training Centre for Innovation in Biomedical Imaging Technology, The University of Queensland, St. Lucia, QLD, 4072, Australia.

Stephen J Kent (SJ)

ARC Centre of Excellence in Convergent Bio-Nano Science & Technology, The University of Melbourne, Melbourne, Australia; Department of Microbiology and Immunology, Peter Doherty Institute for Infection and Immunity, The University of Melbourne, Melbourne, VIC, 3000, Australia; Melbourne Sexual Health Centre and Department of Infectious Diseases, Alfred Health, Central Clinical School, Monash University, Melbourne, VIC, 3800, Australia.

Kristian Kempe (K)

ARC Centre of Excellence in Convergent Bio-Nano Science & Technology, and Drug Delivery, Disposition and Dynamics, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, VIC, 3052, Australia; Materials Science and Engineering, Monash University, Clayton, VIC, 3800, Australia. Electronic address: kristian.kempe@monash.edu.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Interactions of core cross-linked...
questionsmedicales.fr › Préparations pharmaceutiques › Micelles › Interactions of core cross-linked...
questionsmedicales.fr › Composés hétérocycliques › Composés hétéromonocycliques › Oxazines › Interactions of core cross-linked...
questionsmedicales.fr › Composés hétérocycliques › Composés hétéromonocycliques › Azoles › Oxazoles › Interactions of core cross-linked...
questionsmedicales.fr › Phénomènes chimiques › Polymérisation › Interactions of core cross-linked...
questionsmedicales.fr › Technologie, industrie et agriculture › Produits manufacturés › Matériaux biomédicaux et dentaires › Polymères › Interactions of core cross-linked...