Inhibition of human sperm motility and capacitation by ziram is mediated by decreasing tyrosine protein kinase.

Calcium ion influx Environmental endocrine disruptors Sperm Sperm motility Tyrosine protein kinase Ziram

Journal

Ecotoxicology and environmental safety
ISSN: 1090-2414
Titre abrégé: Ecotoxicol Environ Saf
Pays: Netherlands
ID NLM: 7805381

Informations de publication

Date de publication:
10 May 2021
Historique:
received: 20 11 2020
revised: 19 04 2021
accepted: 20 04 2021
pubmed: 14 5 2021
medline: 14 5 2021
entrez: 13 5 2021
Statut: aheadofprint

Résumé

Many endocrine disruptors may interfere with sperm motility, hyperactivation, and capacitation, thereby leading to male infertility. In the current study, we screened 14 endocrine disruptors, including plant ingredients, cigarette ingredients, minerals, insecticides and fungicides, plastics, and plasticizers, to inhibit human sperm motility and forward motility. Only ziram, a dithiocarbamate fungicide, can effectively inhibit sperm motility, forward motility, hyperactivation, capacitation, and spontaneous acrosome reaction of normal human spermatozoa. Its half maximum inhibitory concentration (IC

Identifiants

DOI: 10.1016/j.ecoenv.2021.112281 PMID: 33984659
pubmed: 33984659
pii: S0147-6513(21)00392-4
doi: 10.1016/j.ecoenv.2021.112281
pii:
doi:

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

112281

Informations de copyright

Copyright © 2021. Published by Elsevier Inc.

Auteurs

Zina Wen (Z)

Department of Obstetrics and Gynecology, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, 109 Xueyuan West Road, Wenzhou, Zhejiang 325027, China.

Zhen Lei (Z)

Department of Andrology, Chengdu Xi'nan Gynecological Hospital and Chengdu Jinjiang Maternal and Child Health Hospital, Chengdu, Sichuan, China.

Erpo Tian (E)

Department of Andrology, Chengdu Xi'nan Gynecological Hospital and Chengdu Jinjiang Maternal and Child Health Hospital, Chengdu, Sichuan, China.

Yiyan Wang (Y)

Department of Obstetrics and Gynecology, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, 109 Xueyuan West Road, Wenzhou, Zhejiang 325027, China.

Ying Zhong (Y)

Department of Andrology, Chengdu Xi'nan Gynecological Hospital and Chengdu Jinjiang Maternal and Child Health Hospital, Chengdu, Sichuan, China. Electronic address: yzhong8@yahoo.com.

Ren-Shan Ge (RS)

Department of Obstetrics and Gynecology, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, 109 Xueyuan West Road, Wenzhou, Zhejiang 325027, China. Electronic address: renshan_ge@wmu.edu.cn.

Classifications MeSH