Akathisia and Restless Legs Syndrome: Solving the Dopaminergic Paradox.

Dopamine / metabolism Humans Psychomotor Agitation / etiology Restless Legs Syndrome / diagnosis
Adenosine Akathisia Dopamine Glutamate Receptor heteromers Restless legs syndrome Striatum

Journal

Sleep medicine clinics
ISSN: 1556-4088
Titre abrégé: Sleep Med Clin
Pays: United States
ID NLM: 101271531

Informations de publication

Date de publication:
Jun 2021
Historique:
entrez: 14 5 2021
pubmed: 15 5 2021
medline: 14 7 2021
Statut: ppublish

Résumé

Akathisia is an urgent need to move that is associated with treatment with dopamine receptor blocking agents (DRBAs) and with restless legs syndrome (RLS). The pathogenetic mechanism of akathisia has not been resolved. This article proposes that it involves an increased presynaptic dopaminergic transmission in the ventral striatum and concomitant strong activation of postsynaptic dopamine D

Identifiants

DOI: 10.1016/j.jsmc.2021.02.012 PMID: 33985651
pubmed: 33985651
pii: S1556-407X(21)00014-X
doi: 10.1016/j.jsmc.2021.02.012
pii:
doi:

Substances chimiques

Dopamine VTD58H1Z2X

Types de publication

Journal Article Review

Langues

eng

Sous-ensembles de citation

IM

Pagination

249-267

Informations de copyright

Published by Elsevier Inc.

Déclaration de conflit d'intérêts

Disclosure The authors have nothing to disclose.

Auteurs

Sergi Ferré (S)

Integrative Neurobiology Section, Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, Triad Building, 333 Cassell Drive, Baltimore, MD 21224, USA. Electronic address: sferre@intra.nida.nih.gov.

Xavier Guitart (X)

Integrative Neurobiology Section, Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, Triad Building, 333 Cassell Drive, Baltimore, MD 21224, USA.

César Quiroz (C)

Integrative Neurobiology Section, Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, Triad Building, 333 Cassell Drive, Baltimore, MD 21224, USA.

William Rea (W)

Integrative Neurobiology Section, Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, Triad Building, 333 Cassell Drive, Baltimore, MD 21224, USA.

Celia García-Malo (C)

Sleep Research Institute, Paseo de la Habana 151, Madrid 28036, Spain.

Diego Garcia-Borreguero (D)

Sleep Research Institute, Paseo de la Habana 151, Madrid 28036, Spain.

Richard P Allen (RP)

Department of Neurology, Johns Hopkins University, Johns Hopkins Bayview Medical Center, 5501 Hopkins Bayview Circle, Baltimore, MD 21224, USA.

Christopher J Earley (CJ)

Department of Neurology, Johns Hopkins University, Johns Hopkins Bayview Medical Center, 5501 Hopkins Bayview Circle, Baltimore, MD 21224, USA.

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Classifications MeSH

questionsmedicales.fr › Composés chimiques organiques › Hydrocarbures › Hydrocarbures cycliques › Hydrocarbures aromatiques › Dérivés du benzène › Phénols › Catéchols › Catécholamines › Dopamine › Akathisia and Restless Legs Syndrome: Solving...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Akathisia and Restless Legs Syndrome: Solving...
questionsmedicales.fr › Comportement et mécanismes comportementaux › Manifestations neurocomportementales › Troubles psychomoteurs › Agitation psychomotrice › Akathisia and Restless Legs Syndrome: Solving...
questionsmedicales.fr › Troubles mentaux › Troubles de la veille et du sommeil › Parasomnies › Syndrome des jambes sans repos › Akathisia and Restless Legs Syndrome: Solving...