Evaluation of radiologic evidence of metabolic bone disease in very low birth weight infants at fourth week of life.
Journal
Journal of perinatology : official journal of the California Perinatal Association
ISSN: 1476-5543
Titre abrégé: J Perinatol
Pays: United States
ID NLM: 8501884
Informations de publication
Date de publication:
11 2021
11 2021
Historique:
received:
26
10
2020
accepted:
22
04
2021
revised:
11
03
2021
pubmed:
15
5
2021
medline:
19
2
2022
entrez:
14
5
2021
Statut:
ppublish
Résumé
The aim of this study is to determine the incidence of metabolic bone disease (MBD) and assess the risk factors for development radiologic evidence of MBD. Preterm infants with gestational age ≤32 weeks and birth weight ≤1500 g were included in this prospective study. Metabolic bone disease was defined as hypophosphatemia (phosphorus levels <4 mg/dl), ALP levels >450 U/L, or radiologic findings of MBD at four weeks of age. The study included 254 infants (gestational age: 29 (27-30) weeks, birth weight: 1130 g (960-1300)). Metabolic bone disease was diagnosed in 96 patients (37%); 48 infants had only radiologic evidence of MBD, 24 infants had only biochemical diagnosis of MBD, and 24 infants had both radiologic evidence of MBD and biochemical diagnosis of MBD. Our results showed that radiologic evidence of MBD existed in some infants with normal biochemical results. That finding may guide further development of screening programs for MBD.
Identifiants
pubmed: 33986471
doi: 10.1038/s41372-021-01065-y
pii: 10.1038/s41372-021-01065-y
pmc: PMC8117125
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
2668-2673Informations de copyright
© 2021. The Author(s), under exclusive licence to Springer Nature America, Inc.
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