Modeling colorectal cancer evolution.
Journal
Journal of human genetics
ISSN: 1435-232X
Titre abrégé: J Hum Genet
Pays: England
ID NLM: 9808008
Informations de publication
Date de publication:
Sep 2021
Sep 2021
Historique:
received:
02
03
2021
accepted:
13
04
2021
revised:
09
04
2021
pubmed:
15
5
2021
medline:
6
1
2022
entrez:
14
5
2021
Statut:
ppublish
Résumé
Understanding cancer evolution provides a clue to tackle therapeutic difficulties in colorectal cancer. In this review, together with related works, we will introduce a series of our studies, in which we constructed an evolutionary model of colorectal cancer by combining genomic analysis and mathematical modeling. In our model, multiple subclones were generated by driver mutation acquisition and subsequent clonal expansion in early-stage tumors. Among the subclones, the one obtaining driver copy number alterations is endowed with malignant potentials to constitute a late-stage tumor in which extensive intratumor heterogeneity is generated by the accumulation of neutral mutations. We will also discuss how to translate our understanding of cancer evolution to a solution to the problem related to therapeutic resistance: mathematical modeling suggests that relapse caused by acquired resistance could be suppressed by utilizing clonal competition between sensitive and resistant clones. Considering the current rate of technological development, modeling cancer evolution by combining genomic analysis and mathematical modeling will be an increasingly important approach for understanding and overcoming cancer.
Identifiants
pubmed: 33986478
doi: 10.1038/s10038-021-00930-0
pii: 10.1038/s10038-021-00930-0
pmc: PMC8384629
doi:
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
869-878Informations de copyright
© 2021. The Author(s).
Références
Nat Genet. 2016 Oct;48(10):1119-30
pubmed: 27526321
Cancer Sci. 2018 Apr;109(4):884-892
pubmed: 29352488
Cell. 2018 Apr 19;173(3):595-610.e11
pubmed: 29656894
Proc Natl Acad Sci U S A. 2011 Dec 6;108(49):19701-6
pubmed: 22106268
Nat Genet. 2019 Jul;51(7):1113-1122
pubmed: 31209394
Curr Opin Genet Dev. 2021 Feb;66:70-77
pubmed: 33434721
Nat Commun. 2019 Jan 16;10(1):246
pubmed: 30651539
Nat Rev Cancer. 2017 Apr;17(4):223-238
pubmed: 28233803
Nature. 2019 Mar;567(7749):479-485
pubmed: 30894752
iScience. 2020 Dec 07;24(1):101901
pubmed: 33364589
Proc Natl Acad Sci U S A. 2015 Nov 24;112(47):E6496-505
pubmed: 26561581
Nature. 1993 Nov 18;366(6452):223-7
pubmed: 8232582
Nat Genet. 2015 Mar;47(3):209-16
pubmed: 25665006
Sci Adv. 2020 Jun 10;6(24):eaay9691
pubmed: 32577507
Cell. 2017 Nov 30;171(6):1259-1271.e11
pubmed: 29107330
Cancer Res. 2009 Jun 1;69(11):4894-903
pubmed: 19487300
Science. 2017 Jul 07;357(6346):55-60
pubmed: 28684519
Cell. 2017 Feb 9;168(4):613-628
pubmed: 28187284
Nat Genet. 2020 Jul;52(7):692-700
pubmed: 32451459
Nat Rev Urol. 2020 Aug;17(8):469-481
pubmed: 32606361
Nature. 2012 Jun 28;486(7404):537-40
pubmed: 22722843
Nat Genet. 2016 Mar;48(3):238-244
pubmed: 26780609
Nat Commun. 2018 Jul 23;9(1):2884
pubmed: 30038269
Philos Trans A Math Phys Eng Sci. 2010 Nov 13;368(1930):5029-44
pubmed: 20921010
Cancer Discov. 2018 Oct;8(10):1270-1285
pubmed: 30166348
Cancer Res. 2010 Jan 1;70(1):46-56
pubmed: 20048071
N Engl J Med. 2012 Mar 8;366(10):883-892
pubmed: 22397650
Nat Commun. 2020 Apr 24;11(1):1993
pubmed: 32332722
PLoS Genet. 2016 Feb 18;12(2):e1005778
pubmed: 26890883
Nat Med. 2015 Jul;21(7):795-801
pubmed: 26030179
Cancer Discov. 2017 Jul 20;:
pubmed: 28729406
Genome Biol. 2018 Dec 3;19(1):211
pubmed: 30509292
Cell. 1990 Jun 1;61(5):759-67
pubmed: 2188735
PLoS Genet. 2021 Jan 21;17(1):e1009113
pubmed: 33476333
Cancer Res. 2015 Nov 15;75(22):4675-80
pubmed: 26527288
Nat Med. 2019 Oct;25(10):1549-1559
pubmed: 31591606
Cell. 2018 Jun 14;173(7):1755-1769.e22
pubmed: 29754820
Cell. 2013 Apr 25;153(3):666-77
pubmed: 23622249
Gastroenterology. 2010 Jun;138(6):2073-2087.e3
pubmed: 20420947
Trends Ecol Evol. 2010 Jul;25(7):410-8
pubmed: 20488578
Clin Transl Gastroenterol. 2020 Dec;11(12):e00269
pubmed: 33512809
Science. 1976 Oct 1;194(4260):23-8
pubmed: 959840
Sci Transl Med. 2016 Feb 24;8(327):327ra24
pubmed: 26912903
PeerJ. 2020 Apr 8;8:e8842
pubmed: 32296600
Nat Biotechnol. 2021 May;39(5):599-608
pubmed: 33462507
Nat Ecol Evol. 2018 Oct;2(10):1661-1672
pubmed: 30177804
Mol Cell. 2019 Mar 21;73(6):1292-1305.e8
pubmed: 30765193
Proc Natl Acad Sci U S A. 2002 Oct 1;99(20):13085-9
pubmed: 12351679
Nat Genet. 2014 Mar;46(3):225-233
pubmed: 24487277