Regulation of Inflammatory Response by Transmembrane Adaptor Protein LST1.
Animals
Biomarkers
Colitis
/ etiology
Dendritic Cells
/ immunology
Disease Models, Animal
Disease Susceptibility
Gene Expression Regulation
Genotype
Humans
Intracellular Signaling Peptides and Proteins
/ genetics
Leukocytes
/ immunology
Lipopolysaccharides
/ immunology
Macrophages
/ immunology
Membrane Proteins
/ genetics
Mice
Mice, Knockout
Phosphorylation
Signal Transduction
LST1
colitis
inflammation
inflammatory bowel disease
myeloid cells
Journal
Frontiers in immunology
ISSN: 1664-3224
Titre abrégé: Front Immunol
Pays: Switzerland
ID NLM: 101560960
Informations de publication
Date de publication:
2021
2021
Historique:
received:
16
10
2020
accepted:
08
04
2021
entrez:
14
5
2021
pubmed:
15
5
2021
medline:
29
6
2021
Statut:
epublish
Résumé
LST1 is a small adaptor protein expressed in leukocytes of myeloid lineage. Due to the binding to protein tyrosine phosphatases SHP1 and SHP2 it was thought to have negative regulatory function in leukocyte signaling. It was also shown to be involved in cytoskeleton regulation and generation of tunneling nanotubes.
Identifiants
pubmed: 33986741
doi: 10.3389/fimmu.2021.618332
pmc: PMC8111073
doi:
Substances chimiques
Biomarkers
0
Intracellular Signaling Peptides and Proteins
0
LST1 protein, human
0
Lipopolysaccharides
0
Membrane Proteins
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
618332Informations de copyright
Copyright © 2021 Fabisik, Tureckova, Pavliuchenko, Kralova, Balounova, Vicikova, Skopcova, Spoutil, Pokorna, Angelisova, Malissen, Prochazka, Sedlacek and Brdicka.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
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