Macrophages contribute to liver repair after monocrotaline-induced liver injury via SDF-1/CXCR4.
C-X-C chemokine receptor type 4
liver repair
macrophage
monocrotaline
stromal cell-derived factor 1
Journal
Experimental and therapeutic medicine
ISSN: 1792-0981
Titre abrégé: Exp Ther Med
Pays: Greece
ID NLM: 101531947
Informations de publication
Date de publication:
Jul 2021
Jul 2021
Historique:
received:
27
11
2020
accepted:
18
02
2021
entrez:
14
5
2021
pubmed:
15
5
2021
medline:
15
5
2021
Statut:
ppublish
Résumé
Monocrotaline (MCT) administration induces liver injury in rodents that mimics the pathology of human sinusoidal obstruction syndrome. MCT-induced SOS models are used to investigate the mechanism of injury and optimize treatment strategies. However, the processes underlying liver repair are largely unknown. Specifically, the role of macrophages, the key drivers of liver repair, has not been elucidated. The current study aimed to examine the role of macrophages in the repair of MCT-induced liver injury in male C57/BL6 mice. Maximal liver injury occurred at 48 h post-MCT treatment, followed by repair at 120 h post-treatment. Immunofluorescence analysis revealed that CD68
Identifiants
pubmed: 33986833
doi: 10.3892/etm.2021.10100
pii: ETM-0-0-10100
pmc: PMC8112113
doi:
Types de publication
Journal Article
Langues
eng
Pagination
668Informations de copyright
Copyright: © Otaka et al.
Déclaration de conflit d'intérêts
The authors declare that they have no competing interests.
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