OPF/PMMA cage system as an alternative approach for the treatment of vertebral corpectomy.
OPF formulation
expandable cage
kinematic testing
minimally invasive surgery
spine
Journal
Applied sciences (Basel, Switzerland)
ISSN: 2076-3417
Titre abrégé: Appl Sci (Basel)
Pays: Switzerland
ID NLM: 101633495
Informations de publication
Date de publication:
Oct 2020
Oct 2020
Historique:
entrez:
14
5
2021
pubmed:
15
5
2021
medline:
15
5
2021
Statut:
ppublish
Résumé
The spinal column is the most common site for bone metastasis. Vertebral metastases with instability have historically been treated with corpectomy of the affected vertebral body and adjacent intervertebral discs, and are more recently treated with separation surgery. With demographics shifting towards an elderly population, a less invasive surgical approach is necessary for the repair of vertebral defects. We have modified a previously reported expandable hollow cage composed of an oligo[poly(ethylene glycol) fumarate] (OPF) containment system that could be delivered via a posterior-only approach. Then, the polymer of interest, poly(methyl methacrylate) (PMMA) bone cement, was injected into the lumen of the cage after expansion to form an OPF/PMMA cage. We compared six different cage formulations to account for vertebral body and defect size, and performed a cage characterization via expansion kinetics and mechanical testing evaluations. Additionally, we investigated the feasibility of the OPF/PMMA cage in providing spine stability via kinematic analyses. The in-vitro placement of the implant using our OPF/PMMA cage system showed improvement and mechanical stability in a flexion motion. The results demonstrated that the formulation and technique presented in the current study have the potential to improve surgical outcomes in minimally invasive procedures on the spine.
Identifiants
pubmed: 33986953
doi: 10.3390/app10196912
pmc: PMC8115301
mid: NIHMS1664191
pii:
doi:
Types de publication
Journal Article
Langues
eng
Subventions
Organisme : NIBIB NIH HHS
ID : F32 EB023723
Pays : United States
Organisme : NIAMS NIH HHS
ID : R01 AR056212
Pays : United States
Déclaration de conflit d'intérêts
Conflicts of interest: No competing financial interests exist.
Références
Can J Neurol Sci. 1987 Feb;14(1):75-80
pubmed: 3815169
Dtsch Arztebl Int. 2011 Feb;108(5):71-9; quiz 80
pubmed: 21311714
Tissue Eng Part A. 2017 Mar;23(5-6):223-232
pubmed: 27835935
Data Brief. 2016 Mar 04;7:614-9
pubmed: 27054167
Eur Spine J. 2006 Feb;15(2):133-48
pubmed: 16292588
Oncologist. 2004;9(2):188-96
pubmed: 15047923
Acc Chem Res. 2019 Aug 20;52(8):2101-2112
pubmed: 31291090
Spine (Phila Pa 1976). 1990 Oct;15(10):1073-8
pubmed: 2263975
Neurosurgery. 2010 Jun;66(6 Suppl Operative):314-8; discussion 318
pubmed: 20489522
Eur Spine J. 2003 Oct;12 Suppl 2:S202-13
pubmed: 14505120
Ann Thorac Surg. 1997 Dec;64(6):1611-8
pubmed: 9436544
Biomacromolecules. 2003 May-Jun;4(3):552-60
pubmed: 12741769
Neurosurg Rev. 2016 Jan;39(1):1-11; discussion 11
pubmed: 26212700
J Biomech Eng. 2016 May;138(5):054502
pubmed: 26974192
J Clin Neurosci. 2017 Oct;44:23-29
pubmed: 28736113
J Neurosurg Spine. 2008 Apr;8(4):341-6
pubmed: 18377319
Eur Spine J. 2011 Feb;20(2):289-96
pubmed: 21132335
Orthop Traumatol Surg Res. 2010 Jun;96(4):456-61
pubmed: 20452304
J Spinal Disord. 1995 Apr;8(2):131-5
pubmed: 7606120
Neurosurg Focus. 2003 Nov 15;15(5):E8
pubmed: 15323465
J Clin Oncol. 2005 Sep 1;23(25):6072-82
pubmed: 16135474
Cancer Control. 2012 Apr;19(2):122-8
pubmed: 22487974