Liver Resection Promotes (Regulates) Proinflammatory Cytokines in Patients with Hepatocellular Carcinoma.
Journal
Canadian journal of gastroenterology & hepatology
ISSN: 2291-2797
Titre abrégé: Can J Gastroenterol Hepatol
Pays: Egypt
ID NLM: 101623613
Informations de publication
Date de publication:
2021
2021
Historique:
received:
26
02
2021
revised:
15
04
2021
accepted:
20
04
2021
entrez:
14
5
2021
pubmed:
15
5
2021
medline:
19
8
2021
Statut:
epublish
Résumé
Several animal studies have shown the roles of cytokines in regulating liver regeneration following liver resection (LR), which is a type of surgery designed to remove cancerous tumors from the liver. This study investigated how the expressions and serum levels of some pro- and anti-inflammatory cytokines in patients with hepatocellular carcinoma (HCC) were changed during LR. Liver tissues from 15 patients with HCC were collected and the levels of interleukin-6 (IL-6), tumor necrosis factor-alpha (TNF- After 60 and 90 minutes of LR, IL-6 gene expression was significantly increased ( Our data provided further evidence to reveal that IL-6 and TNF-
Sections du résumé
Background
Several animal studies have shown the roles of cytokines in regulating liver regeneration following liver resection (LR), which is a type of surgery designed to remove cancerous tumors from the liver. This study investigated how the expressions and serum levels of some pro- and anti-inflammatory cytokines in patients with hepatocellular carcinoma (HCC) were changed during LR.
Methods
Liver tissues from 15 patients with HCC were collected and the levels of interleukin-6 (IL-6), tumor necrosis factor-alpha (TNF-
Results
After 60 and 90 minutes of LR, IL-6 gene expression was significantly increased (
Conclusion
Our data provided further evidence to reveal that IL-6 and TNF-
Identifiants
pubmed: 33987145
doi: 10.1155/2021/5593655
pmc: PMC8093046
doi:
Substances chimiques
Cytokines
0
Tumor Necrosis Factor-alpha
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
5593655Informations de copyright
Copyright © 2021 Farshid Fathi et al.
Déclaration de conflit d'intérêts
The authors declare no conflicts of interest.
Références
Ann Surg Oncol. 2018 Jun;25(6):1454-1455
pubmed: 29616422
Oncogene. 2005 Apr 21;24(18):3028-41
pubmed: 15735717
Liver. 2000 Feb;20(1):66-77
pubmed: 10726963
Hepatology. 1997 Apr;25(4):889-95
pubmed: 9096593
N Engl J Med. 1999 Mar 11;340(10):745-50
pubmed: 10072408
Langenbecks Arch Surg. 2012 Apr;397(4):579-90
pubmed: 22311102
J Biol Chem. 2002 Aug 9;277(32):28411-7
pubmed: 12032149
J Hepatol. 2015 Oct;63(4):917-25
pubmed: 26022689
Proc Natl Acad Sci U S A. 1997 Feb 18;94(4):1441-6
pubmed: 9037072
Hepatology. 2011 Mar;53(3):1020-2
pubmed: 21374666
In Vivo. 2017 Mar-Apr;31(2):209-213
pubmed: 28358702
Hepatology. 2001 Oct;34(4 Pt 1):688-93
pubmed: 11584364
Best Pract Res Clin Gastroenterol. 2014 Oct;28(5):897-908
pubmed: 25260316
J Surg Res. 2006 Dec;136(2):280-7
pubmed: 17046790
Hepatology. 1995 Nov;22(5):1499-506
pubmed: 7590669
Am J Pathol. 2011 Apr;178(4):1614-21
pubmed: 21435447
Liver Int. 2015 Mar;35(3):1036-47
pubmed: 24750853
Int Immunopharmacol. 2013 Feb;15(2):325-32
pubmed: 23337881
Surgery. 1998 Jul;124(1):57-64
pubmed: 9663252
Am J Pathol. 1998 Jun;152(6):1577-89
pubmed: 9626061
Gastroenterology. 2016 Apr;150(4):835-53
pubmed: 26795574
Gastroenterology. 2000 Dec;119(6):1663-71
pubmed: 11113088
J Gastroenterol Hepatol. 2012 Mar;27 Suppl 2:89-93
pubmed: 22320924
Protein Cell. 2015 Aug;6(8):562-74
pubmed: 26088193
Cell Mol Immunol. 2016 May;13(3):316-27
pubmed: 26908374
Ann Surg Oncol. 2010 Dec;17(12):3137-44
pubmed: 20602260
Dig Liver Dis. 2015 Jun;47(6):518-22
pubmed: 25861840
Am J Pathol. 2010 Jan;176(1):2-13
pubmed: 20019184
Hepatoma Res. 2019;5:
pubmed: 31701016
Cell. 2016 Apr 21;165(3):668-78
pubmed: 27062926
Lancet Oncol. 2017 Feb;18(2):e101-e112
pubmed: 28214411
Ann Intern Med. 1988 Mar;108(3):390-401
pubmed: 2449110
World J Gastroenterol. 2009 Dec 14;15(46):5776-83
pubmed: 19998497
Surgery. 2001 Jan;129(1):48-54
pubmed: 11150033
Liver Transpl. 2016 Mar;22(3):344-51
pubmed: 26600439
Curr Stem Cell Res Ther. 2020;15(3):219-232
pubmed: 32077830
Invest New Drugs. 2016 Apr;34(2):255-60
pubmed: 26769245
Hepatol Res. 2002 Oct;24(2):174
pubmed: 12270747
Science. 1996 Nov 22;274(5291):1379-83
pubmed: 8910279
Adv Med Sci. 2015 Mar;60(1):173-7
pubmed: 25794904
Int J Biol Sci. 2020 Jan 22;16(5):893-903
pubmed: 32071558
Trends Immunol. 2013 Sep;34(9):446-52
pubmed: 23668977
Hepatology. 2018 Jan;67(1):358-380
pubmed: 28130846
Methods. 2001 Dec;25(4):402-8
pubmed: 11846609
United European Gastroenterol J. 2019 Jul;7(6):838-849
pubmed: 31316788
JAMA Surg. 2019 Mar 1;154(3):209-217
pubmed: 30422241
PLoS One. 2018 Apr 12;13(4):e0195262
pubmed: 29649247
Cancer Res. 1990 Mar 1;50(5):1464-9
pubmed: 2154324
Ann Hepatol. 2016 Mar-Apr;15(2):260-70
pubmed: 26845604
Proc Natl Acad Sci U S A. 2002 Aug 20;99(17):11181-6
pubmed: 12177410
Int J Cancer. 2001 Oct 15;94(2):153-6
pubmed: 11668491