Transplanted Erythropoietin-Expressing Mesenchymal Stem Cells Promote Pro-survival Gene Expression and Protect Photoreceptors From Sodium Iodate-Induced Cytotoxicity in a Retinal Degeneration Model.
erythropoietin
mesenchymal stem cells
photoreceptors
pro-survival genes
sodium iodate
transcriptome
Journal
Frontiers in cell and developmental biology
ISSN: 2296-634X
Titre abrégé: Front Cell Dev Biol
Pays: Switzerland
ID NLM: 101630250
Informations de publication
Date de publication:
2021
2021
Historique:
received:
11
01
2021
accepted:
29
03
2021
entrez:
14
5
2021
pubmed:
15
5
2021
medline:
15
5
2021
Statut:
epublish
Résumé
Mesenchymal stem cells (MSC) are highly regarded as a potential treatment for retinal degenerative disorders like retinitis pigmentosa and age-related macular degeneration. However, donor cell heterogeneity and inconsistent protocols for transplantation have led to varied outcomes in clinical trials. We previously showed that genetically-modifying MSCs to express erythropoietin (MSC
Identifiants
pubmed: 33987180
doi: 10.3389/fcell.2021.652017
pmc: PMC8111290
doi:
Types de publication
Journal Article
Langues
eng
Pagination
652017Commentaires et corrections
Type : ErratumIn
Informations de copyright
Copyright © 2021 Koh, Alsaeedi, Rashid, Lam, Harun, Ng, Mohd Isa, Then, Bastion, Farhana, Khursheed Alam, Subbiah and Mok.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
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